نتایج جستجو برای: p53

تعداد نتایج: 42422  

ژورنال: :مجله دانشگاه علوم پزشکی سبزوار 0
مهدی نیک بخت رحیم گل محمدی سبزوار، جنب پلیس راه، دانشکده علوم پزشکی و خدمات بهداشتی درمانی سبزوار

زمینه و هدف: سرطان کولورکتال یکی از مهم ترین سرطانهای شایع جهان میباشد. میزان شیوع سرطان کولورکتال بسته به ناحیه جغرافیایی متفاوت میباشد. در سرطان کولورکتال عوامل مختلف محیطی، ژنتیکی و عادت های غذایی نقش دارند. ژن p53 مهم ترین ژن مهارکننده تومور می باشد، میزان موتاسیون اکسون 6 ژن p53 با بیان پروتئین فوق در نمونه های سرطانی کولورکتال در نواحی مختلف، متفاوت گزارش شده است. هدف از این مطالعه تعیین ...

Journal: :iranian journal of pathology 2013
alireza abdollahi sara sheikhbahaei somaye safinejad issa jahanzad

background and objectives: the most prevalent malignancy among women is known to be breast cancer (bc). several factors contribute to determining tumor prognosis and treatment strategies. in this study, the frequency and relevance of these factors are discussed. materials and methods: this cross-sectional study was carried out on 214 patients with bc, who referred to the cancer institute of im...

A Bijhani M Seyed majidi N Keshmii SH Nafarzadeh

Background & Aims: The role of P53 and proliferating cell nuclear antigen (PCNA) genes in inflamed and non-inflamed odontogenic cysts is related to cell proliferation but it is unclear. The aim of this study was immunohistochemical evaluation of P53 and PCNA expression in inflamed and non-inflamed dentigerous cysts Methods: In the present study, 23 dentigerous cysts (12 inflamed and 11 non-infl...

ژورنال: افق دانش 2014
عبدا... زاده, رسول, نوری دلویی, محمدرضا,

چکیده مقدمه: ژن p53، معروف‌ترین ژن بازدارنده توموری است که در بیش از 50% سرطان‌های انسانی دچار جهش می‌شود. این ژن با عنوان‌هایی چون "نگهبان ژنوم"، "ژن فرشته نگهبان" و "استاد نگهبان" توصیف شده است که به نقش حیاتی آن در پایداری ژنومی، و سرکوب توموری عمدتاً با القای آپوپتوز، توقف چرخه سلولی، پیری، و مهار رگ‌زایی اشاره دارد. در این مقاله مروری، پیشرفت‌های اخیر در رابطه با p53، به‌ویژه نقش آن در آپو...

عسگری, مژگان, نوری, صغری,

ABSTRACT Bladder cancer consists of about 5.2% of all cancers in men and 2.3% in women. About 90% of them have the origin of transitional cells(TCC). There are some predictive factors that knowledge of them is useful for management and follow-up of the patients. Expression of oncoprotein P53 is one of these factors. Considering influence of P53 expression on prognosis, we decided ...

Journal: :Cell & Bioscience 2021

Abstract Background Silica exposure underlies the development of silicosis, one most serious occupational hazards worldwide. We aimed to explore interaction silica-induced epithelial–mesenchymal transition (EMT)-related transcripts with cellular metabolism regulated by p53. Methods knocked out p53 using CRISPR/Cas9 in human bronchial epithelial (HBE) cell line. The transcriptomic and metabolomi...

Journal: :E3S web of conferences 2021

P53 is a recognized tumor suppressor gene, which mainly depends on the activity of its transfer factor to realize effect. Mouse two-minute 2 (MDM2) an important inhibitor p53. When combined with MDM2, p53 will be reduced, and anti-cancer effect weakened. According mechanism between researchers focus inhibitors inhibit their binding. Through large number drug screening methods means, this articl...

Journal: :Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) 2023

ABSTRAK
 Astrositoma merupakan salah satu tumor primer susunan saraf pusat yang paling sering ditemukan dibandingkan lainnya. Tujuan penelitian ini adalah untuk mengetahui pola ekspresi protein P53 pada astrositoma berdasarkan derajat histopatologi. Penelitian observasi analitik dengan pendekatan cross sectional dilakukan di Fakultas Kedokteran Universitas Hasanuddin Makassar mulai bulan A...

Journal: :acta medica iranica 0
farzaneh agha-hosseini department of oral and maxillofacial medicine, dental research center, tehran university of medical sciences, tehran, iran and department of oral maxillofacial medicine, school of dentistry, tehran university of medical sciences, tehran, iran and department of oral maxillofacial medicine, the academy of medical sciences, tehran, iran iraj mirzaii-dizgah department of physiology, school of medicine, aja university of medical sciences, tehran, iran najmehsadaat miri-zarandi department of oral and maxillofacial medicine, dental research center, tehran university of medical sciences, tehran, iran

unstimulated whole salivary p53 was evaluated in non-involved subjects, in patients suffering from oral lichen planus (olp) and squamous cell carcinoma (scc). a total of 34 patients with olp, 24 patients suffering from oral scc and 41 non-involved participants were enrolled. the unstimulated whole saliva p53 level was assayed by elisa. data was analyzed by anova followed by the tukey post hoc t...

Journal: :Cancers 2023

p53 plays a critical role in tumor suppression and is the most frequently mutated gene human cancers. Most mutants (mutp53) are missense mutations thus expressed In cancers that retain wtp53, wtp53 activities downregulated through multiple mechanisms. For example, overexpression of negative regulators p53, MDM2/MDMX, can also efficiently destabilize inactivate wtp53. Therefore, both mutp53 have...

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