OBJECTIVE Vulvar intraepithelial neoplasia (VIN) and vulvar Paget disease are managed with either vulvectomy, destructive treatments (laser, antimitotic drugs) or immunostimulants. All these options are associated with functional complications. The purpose of this study was to evaluate the surgical technique consisting of skinning vulvectomy with split-thickness skin graft, and its effect on ov...

Previous studies have shown that immunoassay of urinary NTx (cross-linked N-telopeptides of type I collagen) provides a responsive index of human bone resorption. Here we report by a sensitive immunoassay that NTx is present in serum and is suppressed appropriately in patients with Paget disease of bone by bisphosphonate antiresorptive therapy. The monoclonal antibody (1H11) developed against u...

We present the case of a large, painful pelvic bone tumor in a 53-year-old woman with severe Paget disease. Her presentation was complicated with bilateral total hip arthroplasty, history of spinal stenosis, and multiple lucent lesions in the spine and pelvis in severely affected pagetoid bone. This case features the rare but dreaded complication of osteosarcomatous transformation in Paget dise...

INTRODUCTION Our objective was to evaluate the efficacy of conservative treatment with imiquimod in Paget vulvar disease. MATERIALS AND METHODS We describe a case series that includes 10 patients with histopathologic diagnosis of extramammary Paget disease of the vulva, who were treated with 5% imiquimod cream. Of these patients, 3 were treated for recurrent disease and 7 were treated for ini...

BACKGROUND Paget-Schröetter syndrome is an uncommon form of venous thrombosis, which is related to thoracic outlet syndrome. Axillary-subclavian vein thrombosis typically presents in healthy young adults. We present this case of particular interest because it indicates that a combined treatment involving thrombolysis, anticoagulation therapy, rehabilitation, and elastic compression sleeves can ...

A case of primary upper-extremity deep vein thrombosis (UEDVT) or Paget-Schroetter syndrome is reported. It is effort thrombosis usually affecting young healthy individuals and is a rare condition. Our patient was an elderly male with history of exertion using the left upper limb. He responded to limb elevation and anticoagulation. No other cause for thrombosis was found.

Correspondence To the Editor: A 40‑year‑old male working as a manual labor with a history of smoking presented with a swelling in the neck and right upper extremity with the breathlessness since 5 days. The swelling in the neck region was acute in onset, pain associated with the generalized swelling in a right upper extremity. Breathlessness was acute in onset but was not associated with chest ...

"The major contributions of surgical interest which have been made to our understanding of wound healing since Virchow and Paget rest with quantifying the rate of repair and the appraisal of factors which affect it." (Dunphy, 1960.)

Acknowledgements : We thank Mr. K. Eric Knutsen for providing us with the data collected by him on behalf of Cresap, McCormick, and Paget, Inc. The analysis and interpretation presented here are those of the authors.

PATIENT Male, 16. FINAL DIAGNOSIS Effort thrombosis (Paget-Schroetter Sydnrome). SYMPTOMS Swollen arms. MEDICATION -. CLINICAL PROCEDURE -. SPECIALTY Metabolic Disorders and Diabetics. OBJECTIVE Rare disease. BACKGROUND Thrombotic events in otherwise healthy pediatric patients are rare. In patients presenting with limb swelling, thrombosis must be considered in the differential di...