Cleft palate is a common birth defect in humans and is a common phenotype associated with syndromic mutations in fibroblast growth factor receptor 2 (Fgfr2). Cleft palate occurred in nearly all mice homozygous for the Crouzon syndrome mutation C342Y in the mesenchymal splice form of Fgfr2. Mutant embryos showed delayed palate elevation, stage-specific biphasic changes in palate mesenchymal prol...

Static palatography has been widely used to investigate consonant articulation. The method is based on the observation of the tongue print (a black paste is spread on the tongue before the production) either directly onto the palate (direct palatography) or onto a pseudo palate (indirect palatography). This study has two main objectives. The first one is to provide an automatic analysis of the ...

Oral focal mucinosis (OFM); It is a rare soft tissue lesion of unknown etiology. was first described by Tomich in 1974. usually occurs as localized, asymptomatic pedunculated or sessile growth on the gingiva hard palate. In intraoral examination 14-year-old systemically healthy female patient who applied to our clinic with complaint gingival enlargement maxillary palate region, well-circumscrib...

Van der Woude syndrome or lip pits is a rare genetic autosomal dominant affection that represents the first cause of syndromic cleft and palate. Lower associated not with palate characteristic in this syndrome. The treatment surgical can be very challenging since aesthetic good results hard to achieve We report familial case as only manifestation.

Transcriptional cofactors are essential to the regulation of transforming growth factor beta (TGFbeta) superfamily signaling and play critical and widespread roles during embryonic development, including craniofacial development. We describe the cleft secondary palate 1 (csp1) N-ethyl-N-nitrosourea-induced mouse model of non-syndromic cleft palate (NSCP) that is caused by an intronic Prdm16 spl...

Glucocorticoids (triamcinolone) and dioxins (TCDD) are highly specific teratogens in the mouse, in that cleft palate is the major malformation observed. Glucocorticoids and TCDD both readily cross the yolk sac and placenta and appear in the developing secondary palate. Structure-activity relationships for glucocorticoid- and TCDD-induced cleft palate suggest a receptor involvement. Receptors fo...

The development o f the hard and soft palates in rat foetuses was studied macroscopically and micro­ scopically. The development o f the hard palate followed generally accepted lines and the development o f the rat soft palate was described for the first time. This re­ sembled that o f the hard palate except that there was no rotation o f the posterior part o f the palatal shelf. Closure o f th...

Submucous cleft palate is a missed or forgotten diagnosis. We reviewed 81 patients with submucous cleft palate seen over a 15 year period; 26 of these patients were interviewed. The patients were divided into three main groups according to the referral pattern. Children under 2.5 years were referred by a paediatrician for feeding problems; children aged 2.5-10 were referred mainly by speech the...

schwannoma is a benign encapsulated slow-growing tumor that originates from schwann cells of the peripheral nerve sheath. it usually occurs in the head and neck; however, it is rare in the oral cavity. the tongue is the most common site of intraoral schwannomas, followed by the floor of the mouth, palate, gingiva, vestibular mucosa, lips and mental nerve area. we report a rare case of schwannom...

Cleft palate is one of the most common congenital birth defects. Tremendous efforts have been made over the last decades towards understanding hard palate development. However, little is known about soft palate morphogenesis and myogenesis. Finding an appropriate surgical repair to restore physiological functions of the soft palate in patients with cleft palate is a major challenge for surgeons...