Background . Breast cancer (BC) is the most common female malignancy worldwide. partner and localizer of BRCA2 gene ( PALB2 ) directly involved in DNA damage response. germline mutation has been identified breast familial pancreatic cases, accounting for approximately 1–2% 3–4%, respectively. goal this report was to describe new a young Yakut patient with family history cancer. Material methods...

PURPOSE Familial pancreatic cancer describes families with at least two first-degree relatives with pancreatic cancer that do not fulfil the criteria of other inherited tumor syndromes with increased risks of pancreatic cancer. Although much has been learned regarding the aggregation of pancreatic cancer in some families, the genetic basis for this familial aggregation is poorly understood. Thi...

BACKGROUND Heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C) is a core component of 40S ribonucleoprotein particles that bind pre-mRNAs and influence their processing, stability and export. Breast cancer tumor suppressors BRCA1, BRCA2 and PALB2 form a complex and play key roles in homologous recombination (HR), DNA double strand break (DSB) repair and cell cycle regulation following DNA d...

The breast cancer suppressor BRCA2 is essential for the maintenance of genomic integrity in mammalian cells through its role in DNA repair by homologous recombination (HR). Human BRCA2 is 3,418 amino acids and is comprised of multiple domains that interact with the RAD51 recombinase and other proteins as well as with DNA. To gain insight into the cellular function of BRCA2 in HR, we created fus...

Introduction. At least 3% of all cancer cases are associated with hereditary changes in genes predisposing to malignant neoplasms. In addition the widely known BRCA1,2 genes, other involved equally DNA repair system and maintenance genome integrity, such as PALB2, CHEK2, being introduced into routine diagnosis. this review we present current information from recent studies on structure function...