The pancreas, which lies parallel to and beneath the stomach, is a large compound gland with most of its internal structure similar to that of the salivary glands.The pancreatic digestive enzymes are secreted by pancreatic acini, and large volumes of sodium bicarbonate solution are secreted by the small ductules and larger ducts leading from the acini.The combined product of enzymes and sodium ...

This article briefly describes some anatomical details of the pancreatic duct system in dogs, cats, cattle, sheep, goats, pigs and rats that are important for the preparation of pancreatic ducts for surgery. The advantages and disadvantages of various materials used for preparing cannulas and catheters for the collection of pancreatic juice are also presented. Several techniques of pancreatic d...

Mutations in WNK1 and WNK4, genes encoding members of a novel family of serine-threonine kinases, have recently been shown to cause pseudohypoaldosteronism type II (PHAII), an autosomal dominant disorder featuring hypertension, hyperkalemia, and renal tubular acidosis. The localization of these kinases in the distal nephron and the Cl(-) dependence of these phenotypes suggest that these mutatio...

BACKGROUND & AIMS Pancreatic intraepithelial neoplasia (PanIN) are pancreatic cancer precursor lesions of unclear origin and significance. PanIN aberrantly express sonic hedgehog (Shh), an initiator of pancreatic cancer, and gastrointestinal mucins. A majority of PanIN are thought to arise from ducts. We identified a novel ductal compartment that is gathered in gland-like outpouches (pancreatic...

Pancreatic organogenesis has been a classic example of epitheliomesenchymal interactions. The nature of this interaction, and the way in which endocrine, acinar and ductal cell lineages are generated from the embryonic foregut has not been determined. It has generally been thought that mesenchyme is necessary for all aspects of pancreatic development. In addition islets have been thought to der...

Luo, Xiang, Weizhong Zheng, Ming Yan, Min Goo Lee, and Shmuel Muallem. Multiple functional P2X and P2Y receptors in the luminal and basolateral membranes of pancreatic duct cells. Am. J. Physiol. 277 (Cell Physiol. 46): C205–C215, 1999.—Purinergic receptors in the basolateral and luminal membranes of the pancreatic duct can act by a feedback mechanism to coordinate transport activity in the two...

The specialised epithelia lining the respiratory tract, pancreatic ducts, male genital ducts and sweat gland ducts are defective in the severe inherited disease, cystic fibrosis (CF). We have looked at the expression of the CF gene in human fetal tissues to throw light on the development of function in specialised ductal epithelia and to determine the age of onset of the CF disease process. The...

A 13-year-old spayed female Siamese cat was submitted for necropsy following unsuccessful treatment for obstructive jaundice. Histopathologic examination revealed an adenocarcinoma of the hepatopancreatic ampulla. The carcinoma obstructed the pancreatic and common bile ducts entering the ampulla, resulting in severe diffuse acinar degeneration, atrophy and fibrosis of the pancreas, and dilatati...

The present paper describes clinical observation of successful treatment a patient with chronic calcifying pancreatitis complicated by an external pancreatic fistula. Abdominal surgery after laparotomy and cholecystectomy had to be limited bursoomentostomy due the bleeding tissues severe blood loss. Combined endoscopic intervention through fistula was used for treatment. performed interventions...