The transcription factor CLOCK-BMAL1 is a core component of the molecular clock machinery that drives circadian gene expression and physiology in mammals. Recently, we reported that this heterodimeric transcription factor functions as a signaling molecule in response to the resetting stimuli via the Ca²+-dependent protein kinase C pathway. Here, we demonstrate that the CREB-binding protein (CBP...

We investigated the role of nitric oxide on rapid (25- and 40-minute) baroreceptor resetting during the onset of acute hypertension in rats treated with NG-nitro-L-arginine, an inhibitor of nitric oxide synthesis, and methylene blue, an inhibitor of guanylate cyclase. The effect of treatment with glibenclamide, an ATP-dependent K+ channel blocker, was also investigated. Arterial hypertension wa...

This review addresses issues of various drift–diffusion and inhomogeneous advection problems with without resetting on comblike structures. Both a Brownian diffusion search drift an the comb structures are analyzed. The analytical results verified by numerical simulations in terms coupled Langevin equations for structure. subordination approach is one main technical methods used here, we demons...

"Local resetting" was recently introduced to describe stochastic resetting in interacting systems where particles independently try reset a common "origin". Our understanding of such systems, the process is itself affected by interactions, still very limited. One ubiquitous constraint that often imposed on dynamics geometric confinement, e.g. restricting rigid spherical channel so narrow overta...

Serotonin (5-HT) has been strongly implicated in the regulation of the mammalian circadian clock located in the suprachiasmatic nuclei (SCN); however, its role in behavioral (nonphotic) circadian phase resetting remains elusive. Central to this issue are divergent lines of evidence that the SCN may, or may not, be a target for the phase-resetting effects of 5-HT. We have addressed this question...