We report a young patient who developed a stiff man syndrome (SMS) long after remission of Hodgkin lymphoma. This patient is remarkable because he has had several other potentially autoimmune or paraneoplastic neurological syndromes including limbic encephalitis and demyelinating polyneuropathy which also occurred years after remission from Hodgkin disease.

THE neuropsychiatric disturbances occurring in patients with liver disease have been recognized since the time of the Babylonians (Sherlock, I958). Only in the last ten years, however, have their clinical and biochemical significances been appreciated (Walshe, I95 I) (Adams and Foley, 1953). The clinical and EEG findings have been described in detail by Sherlock (I955), Davidson and Summerskill...

Paraneoplastic cerebellar ataxia, also known as paraneoplastic cerebellar degeneration, is one of the wide array of paraneoplastic neurological syndromes in which neurological symptoms are indirectly caused by an underlying malignancy, most commonly gynecological, breast, or lung cancer or Hodgkin's lymphoma. We describe a patient with severe cerebellar dysfunction attributed to a paraneoplasti...

BACKGROUND Paraneoplastic neurological syndromes (PNS) are defined by the presence of cancer and exclusion of other known causes of the neurological symptoms, but this criterion does not separate "true" PNS from neurological syndromes that are coincidental with a cancer. OBJECTIVE To provide more rigorous diagnostic criteria for PNS. METHODS An international panel of neurologists interested...

Silvery hair is a rare clinical feature, common in a group of rare syndromes, which usually present in the paediatric age group termed together as "silvery hair syndromes". We report a consanguineous family in which three out of four siblings had silvery hair and neurological deficits and were diagnosed to have Griscelli syndrome. The diagnosis of Griscelli syndrome in our cases was based on cl...

epilepsy is one of the most common neurological disorders. studies have demonstrated that genetic factors have a strong role in etiology of epilepsy. mutations in genes encoding ion channels, neurotransmitters and other proteins involved in the neuronal biology have been recognized in different types of this disease. moreover, some chromosomal aberration including ring chromosomes will result i...

Although epilepsy syndromes have been recognized for over 50 years, no formally accepted International League Against Epilepsy (ILAE) classification of has existed until recently. The ILAE Task Force on Nosology and Definitions Taskforce (2017–2021) defined an syndrome as “a characteristic cluster clinical electroencephalographic features, often supported by specific etiological findings (s...

Parvovirus B19 has been linked with various clinical syndromes including neurological manifestations. However, its role in the latter remains not completely understood. Although the last 10 years witnessed a surge of case reports on B19-associated neurological aspects, the literature data remains scattered and heterogeneous, and epidemiological information on the incidence of B19-associated neu...