The effects of consanguineous marriages in various isonymic groups have been investigated. The families like Qureshi, Malik, Jats and Sheikh show higher live-births, prenatal and postnatal loss, and percentage pregnancies in the first cousin and 'all related' parental relationships compared to other groups. Syed, Butt, and Mughals show higher percentage of prenatal and postnatal loss, livebirth...

BACKGROUND Anencephaly is a neural tube defect incompatible with life. The aim of this prospective study was to determine the prevalence of anencephaly in Gorgan, northern Iran. METHODS During 1998 - 2005, 49,534 newborns at Dezyani hospital in Gorgan were screened for neural tube defects. Clinical and demographic data of the diagnosed cases were recorded in a pre-designed questionnaire for a...

OBJECTIVE To assess birth and gene frequencies of specific autosomal recessively inborn errors of metabolism (IEM) within different ethnic groups. DESIGN Retrospective study in a regional centre for investigation and treatment of IEM. SUBJECTS All children born within the West Midlands NHS Region, UK, during the decade immediately preceding the 1991 National Census. METHODS Birth frequenc...

The purpose of this study was to assess the onset of independent ambulation relative to possible relationships with maternal and infant characteristics. In a cross-sectional study, the health files of 1,553 Turkish children aged 12-23 months were selected by the multistage sampling method in the Nomenclature of Territorial Units for Statistics (NUTS) regions coded as low, medium and high malnut...

BACKGROUND Congenital heart diseases (CHD) constitute a common cause of birth defects with a multifactorial inheritance background. OBJECTIVES to check for the dysmorphic features, consanguinity and cytogenetic pattern that may be associated with congenital heart disease in Egyptian cases from Mansoura, Egypt. METHODS This work is a pilot prospective controlled study including randomly sele...

OBJECTIVE To investigate the influence of consanguineous marriage on male factor infertility in Lebanon, where rates of consanguineous marriage remain high (29.6% among Muslims, 16.5% among Christians). DESIGN Clinic-based, case-control study, using reproductive history, risk factor interview, and laboratory-based semen analysis. SETTING Two IVF clinics in Beirut, Lebanon, during an 8-month...

OBJECTIVE To determine the risk factors for premature myocardial infarction among young South Asians. DESIGN AND SETTING Case-control study in a hospital admitting unselected patients with non-fatal acute myocardial infarction. METHODS AND SUBJECTS Risk factor assessment was done in 193 subjects aged 15-45 years with a first acute myocardial infarct, and in 193 age, sex, and neighbourhood m...

Objective: To determine the risk factors for premature myocardial infarction among young South Asians. Design and setting: Case–control study in a hospital admitting unselected patients with non-fatal acute myocardial infarction. Methods and subjects: Risk factor assessment was done in 193 subjects aged 15–45 years with a first acute myocardial infarct, and in 193 age, sex, and neighbourhood ma...

Abstract Background Autism spectrum disorder (ASD) is one of the most common neurodevelopmental disorders. In DSM-IV, diagnostic criteria autism consisted three domains: impairment in social interaction, communication deficits, and stereotypic behavior, while DSM-5 they were condensed into two deficits restricted patterns behavior to which sensory processing (SPD) added, manifested by hypo- or ...