Background Clot waveform analysis (CWA) based on activated partial thromboplastin time (APTT) is a useful assay for hemostasis. However, the effects of activators and phospholipid conditions CWA have not been adequately investigated. Therefore, we characterized using four different APTT reagents.

We describe here a test for lupus anticoagulants based on a modified Russell viper venom time (RVVT). using limiting amounts of phospholipid and venom. We have studied 29 patients with a prolonged dilute RVVT. Five of the 29 had a normal activated partial thromboplastin time and three of 1 4 tested by the tissue thromboplastin inhibition test were normal. In 1 7 of 1 9 patients tested. the dilu...

We describe here a test for lupus anticoagulants based on a modified Russell viper venom time (RVVT). using limiting amounts of phospholipid and venom. We have studied 29 patients with a prolonged dilute RVVT. Five of the 29 had a normal activated partial thromboplastin time and three of 1 4 tested by the tissue thromboplastin inhibition test were normal. In 1 7 of 1 9 patients tested. the dilu...