Introduction The relative anisotropy (RA) exhibits a great contrast between brain white and gray matters [1]. However, RA is susceptible to the influence of noise [2, 3]. Although the proposed inter-voxel indices reduce noise influence on measured diffusion anisotropy [3], the partial volume effect originating from the inter-voxel operation adds uncertainty to the estimated anisotropy depending...

Due to the finite spatial resolution of imaging devices, a single voxel in a medical image may be composed of mixture of tissue types, an effect known as partial volume effect (PVE). Partial volume estimation, that is, the estimation of the amount of each tissue type within each voxel, has received considerable interest in recent years. Much of this work has been focused on the mixel model, a s...

BACKGROUND The partial specific volume of a protein is an experimental quantity containing information about solute-solvent interactions and protein hydration. We use a hydration-shell model to partition the partial specific volume into an intrinsic volume occupied by the protein and a change in the volume occupied by the solvent resulting from the solvent interactions with the protein. We seek...