PURPOSE The aim of the present study was to compare the dose distribution generated from photon volumetric modulated arc therapy (VMAT), intensity modulated proton therapy (IMPT), and intensity modulated carbon ion therapy (IMCIT) in the delivery of hypo-fractionated thoracic radiotherapy. METHODS AND MATERIALS Ten selected patients who underwent thoracic particle therapy between 2015 and 201...

This review article provides a systematic overview of the currently available evidence on the clinical effectiveness of particle therapy for the treatment of non-small cell lung cancer and summarizes findings of in silico comparative planning studies. Furthermore, technical issues and dosimetric uncertainties with respect to thoracic particle therapy are discussed.

AIM Recent data suggests that LDL particle concentration, as determined by Nuclear Magnetic Resonance (NMR) spectroscopy, may be associated with cardiovascular risk. We sought to determine the effect of randomization to pravastatin therapy on LDL particle concentration-NMR, among a primary prevention population. METHODS AND RESULTS LDL particle concentration-NMR, LDL size-NMR, and standard ch...

The Particle Therapy Patient Scheduling Problem arises in radiotherapy used for cancer treatment. Previous contributions in the existing literature primarily dealt with photon and electron therapy with a one-to-one correspondence of treatment rooms and accelerators. In particle therapy, however, a single accelerator serves multiple rooms in an interleaved way. This leads to a novel scenario in ...

Hiroshi Akiyama, Ph.D. Kenta Mochizuki Masumi Umezawa OVERVIEW: Hitachi has drawn on the beam control technology it built up through its participation in large accelerator projects to enter the market for particle therapy systems, with five facilities currently in operation and five more in commissioning or under construction. Current marketing focuses on systems that use the spot scanning tech...

A national project for a Swedish Proton Therapy Centre (SPTC) supported by the Swedish university hospitals was formed in 2003. The aim of the SPTC project was to build a national proton therapy centre focused on combining patient treatment and clinical research. The centre was to be operated under the principle of shared governance and distributed competence meaning that the preparations befor...

An α-particle, a (4)He nucleus, is exquisitely cytotoxic and indifferent to many limitations associated with conventional chemo- and radiotherapy. The exquisite cytotoxicity of α-radiation, the result of its high mean energy deposition [high linear energy transfer (LET)] and limited range in tissue, provides for a highly controlled therapeutic modality that can be targeted to selected malignant...

Treatment planning for particle therapy is currently an active field of research due uncertainty in how to modify physical dose in order to create a uniform biological dose response in the target. A novel treatment plan optimization strategy based on measurable nanodosimetric quantities rather than biophysical models is proposed in this work. Simplified proton and carbon treatment plans were si...

The National Accelerator Centre (NAC) is the only particle therapy facility in the Southern Hemisphere and the only one in the world where both high energy neutrons and high energy protons are used for patient treatment. Routine treatment began on the p( 66)/Be isocentric neutron therapy unit in 1989 and 764 patients had been treated in a variety of clinical protocols up to September 1995. The ...