abstract: introduction: nitric oxide (no) is a retrograde messenger in hippocampal synaptic plasticity which involves in learning and memory processes. previous studies revealed that hippocampal pyramidal cells contain no synthase (nos) enzyme which produce no and could be a promising target to evaluate the role of no in brain cognitive functions. so in this study, using nos inhibitor (l-name),...

The effect of scopolamine on the consolidation and forgetting of emotional memory has not been completely elucidated yet. The aim of the present study was to investigate the time course of scopolamine effect on consolidation and forgetting of passive avoidance response. In a first experiment of the present study, we tested the effect of scopolamine (1mg/kg, i.p., immediately after acquisition),...

background: it has been known that brain-derived neurotrophic factor (bdnf) is involved in neural survival and long term memory (ltm). here we hypothesized that bdnf as a potent neurotrophic factor might modulate amnestic effect induced by morphine. objectives: the aim of this study was to examine whether infusion of exogenous bdnf in the ca1 regions of the dorsal hippocampi could ameliorate me...

The authors evaluated competing theories that attribute psychopathic individuals' poor passive avoidance to a strong activating system, a weak inhibitory system, or poor modulation of behavioral activation when inhibitory cues appear. In Study 1, the continuous motor task involved a reward phase to elicit the activating system followed by a passive avoidance phase. Study 2 tested the generality...

Introduction: In the recent years, the use of several drugs such as cocaine and morphine has reduced, but the use of "club drugs" has increased in many countries. 3, 4-methylenedioxymethamphetamine (MDMA) which has known as ‘ecstasy’ among people has many harmful effects on serotonergic system in the brain. This system is responsible for learning and memory. In this study, we tested sub-acute a...

Introduction: Protein kinase M zeta (PKMζ) is assumed to be actively involved in retainig long-term potentiation. The goal of this study was to investigate the role of PKMζ in basolateral amygdala (BLA) upon acquisition, consolidation, retention and retrieval of memory using a specific inhibitor of PKMζ. Methods: Sixty male wistar rats underwent stereotaxic surgery and were cannu...