Intrasegmental patterning in the Drosophila embryo requires the activity of the segment polarity genes. The acquisition of positional information by cells during embryogenesis is reflected in the dynamic patterns of expression of several of these genes. In the case of patched, early ubiquitous expression is followed by its repression in the anterior portion of each parasegment; subsequently eac...

Nowadays, an increasing number of applications uses deserialization. This technique, based on rebuilding the instance objects from serialized byte streams, can be dangerous since it open application to attacks such as remote code execution (RCE) if data deserialize is originating untrusted source. Deserialization vulnerabilities are so critical that they in OWASP's list top 10 security risks fo...

TheHedgehog (Hh) signaling response is regulated by the interaction of three key components that include the sonic hedgehog (Shh) ligand, its receptor patched 1 (Ptch1) and the pathway activator smoothened (Smo). Under the prevailing model of Shh pathway activation, the binding of Shh to Ptch1 (the keyShh receptor) results in the release of Ptch1-mediated inhibition of Smo, leading to Smo activ...

The Hedgehog/Patched signaling pathway plays a prominent role during mammalian development but it is also involved in oncogenic transformation. We investigated the methylation status of the Patched promotor in a set of basocellular carcinomas of the skin and ovarian tumors as an alternative to mutational causes of the pathway deregulation. Our aim was to define a possible role of genetic and/or...