Objective: Early year experiences with parents play an important role in the development of personality of individuals. In this regard, the present study aimed at assessing the relationship between parental bonding and type and severity of psychopathology in young adults.  Methods: A total of 361 students (205 boys and 156 girls) of Tabriz University were selected by cluster sampling me...

Dasatinib, a dual tyrosine kinase inhibitor, is known to modulate or suppress T-cell activation and proliferation. We report a series of 8 patients who developed chronic peripheral lymphocytosis, identified as natural killer cells or natural killer/T-cells based on their large granular lymphocyte morphologies and CD16(+), CD56(+), CD3(-) or CD3(+) immunophenotypic profiles, out of 18 patients r...

Many lines of data, initial epidemiologic studies as well as subsequent extensive experimental studies, indicate that early-life events play a powerful role in influencing later suceptibility to certain chronic diseases. Such events might be over- or undernutrition, exposure to environmental toxins, but also changes in hormones, in particular stress hormones. Typically, those events are trigger...

cytes during anti-T lymphocyte therapy might define a subgroup of transplant recipients at risk for PrLD. Monitoring the percentage of CD19+ lymphocytes during anti-T cell therapy allowed early modification of the immunosuppressive and antiviral regimen. apparently with favorable alteration in the lymphoproliferative process. This preliminary experience suggests that reduction in overall immuno...

Combined cytogenetic, fluorescence in situ hybridization (FISH), and molecular analysis are useful in the diagnosis of sex chromosome aberrations. These methods were used in karyotype analysis of a 4-year-old girl with mild dysmorphism and growth retardation. Standard cytogenetic and FISH analysis was done on slides obtained from peripheral blood lymphocyte culture, and the molecular study was ...

A patient with recurrent summer depression for seven consecutive years is described, whose mood significantly worsened with increased environmental temperature. She had a family history of recurrent summer depression in both her brother and paternal grandmother with symptoms similar to those of typical endogenous depression. The patient's mood switched to hypomania with antidepressant therapy.

We have investigated a family in which three siblings with the autosomal dominant disorder tuberous sclerosis had unaffected parents. The family were typed for polymorphic markers spanning the two genes known to cause tuberous sclerosis located at 9q34 (TSC1) and 16p13.3 (TSC2). TSC1 markers showed different maternal and paternal haplotypes in affected children, excluding a mutation in TSC1 as ...

VACTERL association is a rare disorder with various congenital malformations. The aetiology remains unknown. Combination of at least three congenital anomalies of the following criteria is required for diagnosis: vertebral defects, anal atresia, cardiac anomalies, tracheo-esophageal fistula, renal anomalies, and limb defects. The first case was 1-day old male neonate with multiple congenital an...