A new approach in drug delivery system design for meeting the needs that are associated with certain circadian variations is presented. The system is comprised of a pure compressed drug disk, which is encased by a polymeric coat using hydroxypropylmethylcellulose or polyethylene oxide. Within the polymeric coat, a physiologically acceptable binary electrolyte combination such as sodium deoxycho...

We compared different methods (absorbance, fluorescent dye-binding, and digital PCR) for measuring the concentrations of human genomic DNA from cultured cells and absorbance measurements of a synthetic DNA oligonucleotide. NIST Standard Reference Material (SRM) 2082, a pathlength absorbance standard, was used to benchmark the absorbance measurements done with microvolume spectrophotometers and ...

This work analytically examines some dependences of the differential pathlength factor (DPF) for steady-state photon diffusion in a homogeneous medium on the shape, dimension, and absorption and reduced scattering coefficients of the medium. The medium geometries considered include a semi-infinite geometry, an infinite-length cylinder evaluated along the azimuthal direction, and a sphere. Stead...

We describe a new model of electron transport mechanics, the method by which an electron is transported geometrically in an in®nite medium as a function of pathlength, s, the accumulated elastic multiple-scattering angular de ̄ection characterized by H…s†, the polar scattering angle, and U, a random azimuthal angle. This model requires only one sample of the multiple-scattering angle yet it repr...

In this paper we show how to derive the mean and variance of the transilluminated signal obtained in models of light propagation in tissue, based both on a stochastic Monte Carlo method and on a deterministic diffusion approximation. The theoretical treatment of the Monte Carlo model applies only to integrated intensity measurements, whereas the diffusion approximation gives an estimator for th...

Localized changes in the density of water induced by the presence of an acoustic field cause perturbations in the localized refractive index. This relationship has given rise to a number of nonperturbing optical metrology techniques for recording measurement parameters from underwater acoustic fields. A method that has been recently developed involves the use of a Laser Doppler Vibrometer (LDV)...

We present a noise estimation and subtraction algorithm capable of increasing the sensitivity heterodyne laser interferometers by one order magnitude. The interferometer is specially designed for dynamic measurements test mass in application sub-Hz inertial sensing. A floor 3.31×10−11m/Hz at 100 mHz achieved after applying our to benchtop prototype that showed level 2.76×10−10m/Hz when tested v...