Germline pathogenic mutations in BRCA1 increase risk of developing breast cancer. Screening for mutations in BRCA1 frequently identifies sequence variants of unknown pathogenicity and recent work has aimed to develop methods for determining pathogenicity. We previously observed that tumor DNA methylation can differentiate BRCA1-mutated from BRCA1-wild type tumors. We hypothesized that we could ...

Infectious bursal disease virus (IBDV) causes an economically significant disease of chickens worldwide. Very virulent IBDV (vvIBDV) strains have emerged and induce as much as 60% mortality. The molecular basis for vvIBDV pathogenicity is not understood, and the relative contributions of the two genome segments, A and B, to this phenomenon are not known. Isolate 94432 has been shown previously ...

The genus Mycobacterium include a great number of non-pathogenic organisms as well as some pathogenic species which cause tuberculosis in mammals, birds and cold-blooded animals. The differentiation between pathogenic strains and non-pathogenic ones is based on the lethal properties of the bacilli for experimental animals, particularly the guinea pig. A strain is not considered pathogenic when ...

cerato-ulmin is the most important toxin of fungal causal agents of dutch elm disease and its content is one of the most important factors to distinguish two species ophiostoma ulmi and o. novo-ulmi. with attention to the ophiostoma novo-ulmi is more pathogenicity than o. ulmi, this research was carried out to discuss the role of cerato-ulmin on pathogenicity of causal agent using measurement o...

In declining broadleaf forests in western Ukraine, several Phytophthora species including P. plurivora, bilorbang, polonica, gonapodyides and cactorum were recovered using soil baiting assays identified morphological molecular methods. Pathogenicity tests of selected isolates performed on black alder (Alnus glutinosa (L.) Gaerth.) silver birch (Betula pendula Roth.) to assess susceptibility the...

Macrophomina phaseolina (Tassi) Goid is one of the most important soil-borne fungi that affects sesame and causes charcoal rot disease, with a great economic challenge to growers worldwide. Pathogenic molecular characterizations eleven M. isolates collected from different geographical regions in Egypt were carried out determine pathogenicity genetic diversity. Pathogenicity tests showed pathoge...

Shot hole disease of stone fruit trees, caused by Wilsonomyces carpophilus (Lév.) Adaskaveg, Ogawa & Butler(= Stigmina carpophila (Lév.) M.B. Ellis and Coryneum beijerinckii Oud.) is a serious disease of Prunus species in West Azerbaijan province. The pathogen was obtained from infected leaves, fruits and twigs of Prunus orchards during spring and summer of 2007. Samples were cultured on PDA, M...

Incidences of leukopenia caused by bacteremia have increased significantly and it is associated with prolonged hospital stay and increased cost. Immunoproteomic is a promising method to identify pathogenicity factors of different diseases. In the present study, we used immunoproteomic to analysis the pathogenicity factors in leukopenia caused by Klebsiella Pneumonia bacteremia. Approximately 40...

Confirming the pathogenicity of mitochondrial tRNA point mutations is one of the classical challenges in the field of mitochondrial medicine. In addition to genetic and functional studies, the evaluation of a genetic change using a pathogenicity scoring system is extremely useful to discriminate between disease-causing mutations from neutral polymorphisms. The pathogenicity scoring system is ve...

We used detailed phylogenetic trees for human mtDNA, combined with pathogenicity predictions for each amino acid change, to evaluate selection on mtDNA-encoded protein variants. Protein variants with high pathogenicity scores were significantly rarer in the older branches of the tree. Variants that have formed and survived multiple times in the human phylogenetics tree had significantly lower p...