UNLABELLED MicroRNAs are a new class of small non-protein-coding RNAs that sometimes function as tumor suppressors or oncogenes. Aberrant expression and structural alteration of microRNAs have been reported to be involved in tumorigenesis and cancer development. Recently, rs531564/pri-miR-124-1, rs4938723/pri-miR-34b/c, rs7372209/pri-miR-26a-1, rs895819/pre-miR-27a, and rs11134527/pri-miR-218 w...

In contemporary urban development, to improve the quality of public urban spaces has become one of the most outstanding goals of local urban policies, in order to increase pedestrian activities and people’s social interaction. In this context, to promote outdoor thermal comfort has an utmost importance, especially considering the heat island phenomenon. This paper recalls the use of urban desig...

Povzetek. Članek opisuje vpliv kvantizacijske stopnice na kakovost digitalnega videa pri transformacijskem kodiranju videosignala. Transformacijsko kodiranje smo izvedli enkrat s pomočjo diskretne kosinusne transformacije (DCT) in drugič z diskretno valčno transformacijo (DWT). Kodeka DCT in DWT smo implementirali v programskem paketu Matlab-Simulink. Simulirali smo vpliv kvantizacije na kakovo...

Previous studies in vivo reported that processing of primary microRNA (pri-miRNA) is coupled to transcription by RNA polymerase II (RNAP II) and can occur co-transcriptionally. Here we have established a robust in vivo system in which pri-miRNA is transcribed by RNAP II and processed to pre-miRNA in HeLa cell nuclear extracts. We show that both the kinetics and efficiency of pri-miRNA processin...

1α,25-dihydroxyvitamin D₃ (1,25D3) is a powerful differentiation inducer for acute myeloid leukemia (AML) cells. However, 1,25D3 doses required for differentiation of AML cells may cause lethal hypercalcemia in vivo. There is evidence that vitamin D₂ is less toxic than vitamin D₃ in animals. Here, we determined the differentiation effects of novel analogs of 1α,25-dihydroxyvitamin D₂ (1,25D2), ...

Primary microRNA (pri-miRNA) mimics are important mediators of effective gene silencing and are well suited for sustained therapeutic applications. Pri-miRNA mimics are processed in the endogenous miRNA biogenesis pathway, where elements of the secondary RNA structure are crucial for efficient miRNA production. Cleavage of the pri-miRNA to a precursor miRNA (pre-miRNA) by Drosha-DGCR8 typically...

Canonical primary microRNA transcripts (pri-miRNAs) are characterized by a ∼30 bp hairpin flanked by single-stranded regions. These pri-miRNAs are recognized and cleaved by the Microprocessor complex consisting of the Drosha nuclease and its obligate RNA-binding partner DGCR8. It is not well understood how the Microprocessor specifically recognizes pri-miRNA substrates. Here, we show that in ad...

Title: EFFECTS OF ABIOTIC STRESS AND PREDATOR REFUGE ON TERRESTRIAL PREDATOR-PREY INTERACTIONS Danny Lewis, Doctor of Philosophy, 2009 Directed By: Professor Robert F. Denno, Department of Entomology With assistance from: Assistant Professor Daniel Gruner A major goal of ecology has been to understand how abiotic stress modifies species interactions, including predation. In marine habitats, a w...