Length alterations in microsatellite repeats, termed microsatellite instability (MSI), are found in 10-15% of sporadic colon, endometrial, and gastric cancers harboring defects in DNA mismatch repair (MMR) genes We used the microsatellite markers Big Adenine Tract (BAT) 26 and BAT-25 from the reference panel of five markers recommended by the National Cancer Institute to evaluate the incidence ...

Omental tumors are most commonly found in the pediatric population, with hemangiomas being one of rarest types. These can occur any organ, a higher prevalence skin and subcutaneous tissue. Although they extremely rare, omental tumors, including hemangiomas, often involve greater omentum. We present case 70-year-old male patient that presented to our hospital abdominal pain, distension, inabilit...

Radioimmunotherapy (RIT) for pediatric tumors remains in its infancy despite its potential as an attractive therapeutic modality. Most childhood tumors are radiation sensitive, but the side effects of external beam radiation are well recognized. Despite achieving complete remissions with sophisticated combination therapies, treatment failure primarily results from the inability to eradicate min...

Brain tumors are the most common solid tumors in childhood. Glioblastoma multiform (GBM) is the second most common primary brain tumor in adults. It usually affects the cerebral hemispheres of adults at the 6th or 7th decade of life. In comparison to adult population, GBM is rare in pediatrics and accounts for approximately 3% of all pediatric brain tumors. Pediatric glioblastoma was defined as...

INTRODUCTION Oligodendrogliomas (OGs) account for <20% of all intracranial tumors and 25% of gliomas. Despite improvements in imaging techniques allowing for earlier diagnosis, OG is rare among the pediatric population. This study examines a large cohort of OG patients in an effort to define the demographic, clinical, and pathologic factors associated with clinical and survival outcomes. METH...

OBJECTIVE Few studies exist on the demographics and trends of pediatric central nervous system (CNS) tumors in Iran. In this study, we retrospectively reviewed all cases with confirmed CNS tumors admitted to Mofid Pediatric Hospital, Tehran, Iran during the last 18 years. MATERIALS & METHODS Data on gender, age of diagnosis, pathologic classification and tumor location were extracted from the...

PURPOSE To determine the role of methylation of HIC1, a candidate tumor suppressor gene on 17p13.3, in various types of pediatric tumors. EXPERIMENTAL DESIGN We examined the methylation status of the HIC1 promoter by methylation specific PCR in 157 pediatric tumors and 27 nonmalignant tissues. We correlated methylation with mRNA expression by reverse transcription-PCR in eight tumor-derived c...