PURPOSE To determine whether long-term brimonidine (BRI) treatment prevents the hyperglycemia-induced increase in vitreoretinal vascular endothelial growth factor (VEGF) expression and breakdown of the blood-retinal barrier (BRB) in streptozotocin (STZ)-induced diabetic rats. METHODS Brown Norway/Long-Evans rats were divided into three groups with similar distributions of blood glucose and bo...

A primate eye affected by postoperative infectious endophthalmitis was studied early in the course of the disease. Retinal perivasculitis, vitreoretinal adhesions along the inflamed vessels, and traction of the partially separated posterior vitreous on the retina at the adhesion sites were observed. It is suggested that such vitreoretinal junction pathology may be responsible for the developmen...

Introduction The acronym PANDAS reveals a pediatric autoimmune neuropsychiatric disorder associated with Streptococcus pyogenes infection. This disorder is defined by: (a) the presence of obsessive-compulsive disorder (OCD) or tics; (b) abrupt onset and remitting/relapsing course; (c) prepuberal onset of all symptoms; (d) temporal association with a group A b-hemolytic S. pyogenes infection; (e...

Most clinicians and investigators agree that bipolar disorder as currently diagnosed is phenomenologically heterogeneous and probably represents several distinct subtypes. The inability to reliably define distinct subtypes of bipolar disorder has greatly impaired research into the pathophysiology and treatment of the disorder. The articles by Angst and Sellaro (2000), Biederman et al (2000), an...

PURPOSE To describe enhanced vitreous imaging for visualization of anatomic features and microstructures within the posterior vitreous and vitreoretinal interface in healthy eyes using swept-source optical coherence tomography (SS-OCT). The study hypothesis was that long-wavelength, high-speed, volumetric SS-OCT with software registration motion correction and vitreous window display or high-dy...

PURPOSE To investigate vision-related quality of life (VR-QOL) in patients undergoing vitrectomy for various vitreoretinal disorders and to evaluate the relationship between VR-QOL and visual function. METHODS The study included 100 normal control subjects and 299 patients with various vitreoretinal disorders including proliferative diabetic retinopathy (PDR), diabetic macular edema (DME), br...

Objective: The evaluation of intraocular pressure (IOP) after vitreoretinal surgery is critical to ensure the normal function of the eye. The purpose of this study was to determine the incidences and risk factors of early postoperative IOP elevation after vitreoretinal surgery. Method: Data were collected and retrospectively analyzed from 150 patients (150 eyes) who received vitreoretinal surge...

Studies from the USA suggest that rates of pediatric bipolar disorder have increased since the mid-90s, but no study outside the USA has been published on the rates of pediatric bipolar disorder. Further, it is unclear whether an increase in rates reflects a true increase in the illness or more diagnostic attention. Using nationwide registers of all inpatients and outpatients contacts to all ps...