Zebrafish are rapidly growing in popularity as an in vivo model system for chemical genetics, drug discovery, and toxicology, and more recently also for natural product discovery. Experiments involving the pharmacological evaluation of small molecules or natural product extracts in zebrafish bioassays require the effective delivery of these compounds to embryos and larvae. While most samples to...

This work describes the synthesis of platinum-nickel/lanthanum hexaaluminates (PtNi/LHA) and their performance in terms stability catalytic activity dry reforming methane (DRM) at 973 K. An Al solution (9.40 g/L) obtained from an saline slag waste by acid extraction was used to synthesize hexaaluminate mixing with a stoichiometric amount lanthanum nitrate methanol/Peg400/PegMn400 under hydrothe...

In this study the effect of liquisolid technique on the dissolution profile of spironolactone was evaluated. Different formulations of spironolactone liquisolid compacts were prepared using various amounts of non-volatile vehicles (Poly ethylene glycol 400 and glycerin). The ratio of microcrystalline cellulose (as carrier) to silica (as coating powder material) was 20 for all formulations. Afte...

A first attempt was made to prepare cyclic olefin polymer/copolymer (COP/COC) flat-sheet porous membranes by the well-known non-solvent induced phase separation method. In this study, two solvents (chloroform and 1,2,4-trichlorobenzene), different additives (polyvinylpyrrolidone, PVP, polyethylene glycol, PEG400, oxide, PEO, Sorbitan monooleate, Span 80) coagulants (acetone 70/30 wt% acetone/wa...

Abstract: Background: Insomnia is usually associated with mental and physical daytime impairment. Zaleplon (Zp) indicated in insomnia management but its limited aqueous solubility led to low bioavailability (BAV) ~30%. Self-nanoemulsifying drug delivery system (SNEDDS) was a recommended nano-delivery for improvement poorly soluble drugs’ oral bioavailability. Consequently, this study aimed prep...

Emodin is a component in a Chinese herb, Rheum officinale Baill, traditionally used for diabetes and anticancer. Its poor solubility is one of the major challenges to pharmaceutical scientists. We previously reported on thermoreversible gel formulations based on poloxamer for the topical delivery of emodin. The present study was to understand the effect of poloxamer type on emodin solubility an...

Purpose: Lovastatin is poorly water soluble drug. It should be come into the BCS II drug. So oral bioavailability of lovastatin is less (50%). To develop novel dosage foam of the self-microemulsifying drug delivery systems (SMEDDS) for the lovastatin. Methods: Before the formulation of SMEDDS, solubility study was performed in different exicipients and select exicipients on basis of solubility ...