Neuraminidaseis a key enzyme in the life cycle of influenza viruses and is present in some bacterial pathogens. We here assess the inhibitory potency of plant tannins versus clinically used inhibitors on both a viral and a bacterial model neuraminidase by applying the 2'-(4-methylumbelliferyl)-α-d-N-acetylneuraminic acid (MUNANA)-based activity assay. A range of flavan-3-ols, ellagitannins and ...

AIM For EPs-7630, a herbal drug preparation from Pelargonium sidoides roots, therapeutic effects in respiratory tract infections outside the strict indication for antibiotics have already been demonstrated in adults. Now, a dose-finding study for EPs-7630 was performed in children and adolescents. METHODS A total of 400 patients (aged 6-18 years) were randomized to receive either 30 mg, 60 mg...

Submit Manuscript | http://medcraveonline.com HPLC-UV: High Performance Liquid Chromatography And Ultravioleta Detector; HPLC-DAD: High Performance Liquid Chromatography and Diode Array Detector; NCB: Blank Nanocapsules; NCLS: Nanocapsules Containing Essential Oil of L. Sidoides; ODS: Octadecylsilyl Groups; OELS: Essential Oil of Lippia Sidoides; PLGA: Poly D, L-Lactide-Co-Glycolyde; PTFE: Poly...