Phendimetrazine (PDM) is a clinically available anorectic and a candidate pharmacotherapy for cocaine addiction. PDM has been hypothesized to function as a prodrug that requires metabolism to the amphetamine-like monoamine transporter substrate phenmetrazine (PM) to produce its pharmacological effects; however, whether PDM functions as an inactive prodrug or has pharmacological activity on its ...

The product data exchange between heterogeneous CAD and PDM systems is a crucial issue for the integration of product development systems. STEP offers an efficient mechanism of product data exchange between heterogeneous systems. This paper introduces a UML-based mapping methodology for the product data models. The suggested mapping method has been applied to exchange the product structure data...

local community participation in development programs has a long history and wide range of development agencies have tried to involve people in development plans should. in this context, the main purpose of this study was to assess feasibility of participatory management of urban parks, in city of karaj. the study applied a descriptive-survey method of research. the statistical population inclu...

Surface electromyography (sEMG) is used to assess muscle activation during therapeutic exercise, but data are significantly affected by inter-individual variability and requires normalisation of the sEMG signal to enable comparison between individuals. The purpose of this study was to compare two normalisation methods, a maximal method (maximum voluntary isometric contraction (MVIC)) and non-ma...

The growth of mobile devices with near PC equivalent capabilities has brought with it the possibility of mobile Peer-to-Peer (P2P) systems. However, the unique nature of mobile devices introduces new challenges that need to be considered during the development process, especially when considering critical aspects such as system security. This chapter presents the PEPERS Development Methodology ...

Today, product development is characterized by cross-company collaboration and an intensive exchange of product data. Engineers typically apply a multitude of digital engineering tools and act in diverse engineering processes. In a current study, the ―culture‖ of today’s collaborative product development was investigated in significant detail. The questions are: How do engineers work today? Whi...

Primary dysmenorrhea (PDM, menstrual pain without pelvic abnormality) is the most common gynecological disorder for women in the reproductive age. It is characterized by cramping pain and enhanced pain sensitivity during the menstruation period. PDM has been associated with peripheral and central sensitization. Abnormal brain mechanisms may further contribute to development and maintenance of t...

Prognostics-enabled Decision Making (PDM) is an emerging research area that aims to integrate prognostic health information and knowledge about the future operating conditions into the process of selecting subsequent actions for the system. Previous work developing and testing PDM algorithms has been done in simulation; this paper describes the effort leading to a successful demonstration of PD...

In recent years, many panel manufacturers and vendors in Taiwan have invested extensively in liquid crystal display (LCD) due to the increasing demand from all over the world. New types and lager size of LCDs have been designed collaboratively by R&D groups using product data management (PDM) system. However, the key performance indices (KPIs) of PDM system are lack of discussion in LCD industr...

BACKGROUND Pregnant women have been identified as a group at risk, both for respiratory complications than for the admissions to the Intensive Care Unit (ICU) during the 2009 H1N1 influenza pandemic (pdm). The purpose of this prospective register-based cohort-study was to characterize the clinical virulence of the pdm (H1N1/09)v during pregnancy in La Réunion. METHODS/PRINCIPAL FINDINGS Over ...