Infective endocarditis (IE) in people who inject drugs (PWID) is an emergent public health problem. The purpose of this study was to investigate IE PWID and compare it with non-PWID patients. Two prospective cohort studies (ICE-PCS ICE-Plus databases, encompassing 8,112 episodes from 2000 2006 2008 2012, 64 34 sites 28 18 countries, respectively). Outcomes were compared between patients IE. Log...