BACKGROUND AND AIMS The genetic trait plays a part in the pathogenesis of peptic ulcer disease. To identify a DNA marker for peptic ulcer disease, the association between the restriction fragment length polymorphism (RFLP) of the pepsinogen C (PGC) gene and peptic ulcer disease was investigated. PATIENTS AND METHODS One hundred and seventy seven unrelated controls, 75 patients with gastric ul...

For more than a century, peptic ulcer disease has been a major cause of morbidity and mortality. In the early part of the 20th century, when stress and diet were judged to be important pathogenetic factors for peptic ulceration, patients with peptic ulcers were treated with hospitalization, bed rest, and the prescription of “bland” diets. By the 1950s, investigators and clinicians had focused t...

The Development and Assessment of a Herbal Floating Tablet for Peptic Ulcer Disease. goal creating herbal floating tablet is to extend the drugs duration in gastrointestinal tract. This will increase bioavailability result greater absorption than with convectional dose form. Due its gastro-retentive feature, medicine remains at site inflammation longer amount time, resulting more targeted actio...

BACKGROUND The association between stress and peptic ulcers has been questioned since the discovery of helicobacter pylori. This study examined whether high perceived everyday life stress was associated with an increased risk of either receiving a triple treatment or being diagnosed with a peptic ulcer. METHODS Cohen's perceived stress scale measured the level of stress in a general health su...

BACKGROUND Peptic ulcer disease is one of the most common diseases prevalent in developing country like Nepal and with availability of endoscopy there have been increase in diagnosis and therapeutic use of endoscopy. OBJECTIVE The aim of this study is to investigate the prevalence of peptic ulcer disease in patient who came for upper gastrointestinal endoscopy in Kathmandu Medical College Tea...

introduction: helicobacter pylori infections occur in about 50% of the world population and have a main role in the creation of peptic ulcer and its related cancer. we sought to evaluate the effectiveness of two treatment regimens on the eradication of helicobacter pylori and its complications among peptic ulcer patients. materials and methods: by a clinical trial, patients with peptic ulcer sh...

The prevalence of active and inactive peptic ulcer was 23% in male workers aged 31-60 at a plastics processing factory in Tokyo. Similarly, the incidence of active and inactive peptic ulcer during one year was 5% or more. The findings from a case control study suggested that smoking and family history were the major aetiological factors. The incidence and prevalence of peptic ulcer in male fact...

Peptic ulcer bleeding is an internal medical emergency. Endoscopic hemostasis has been shown to improve the survival rate of patients with peptic ulcer bleeding. Although the established hemostatic modalities, including injection, thermal therapy, and mechanical therapy, are effective in controlling peptic ulcer bleeding, hemostasis can be difficult to achieve in some cases. As a result, recent...

Sula, Parinamasula and Amlapitta are clinical entities recognized by ayurveda, akin to peptic ulcer and functional dyspepsia. Many indigenous drugs have been advocated in ayurveda for treatment of dyspepsia. Our laboratory has been engaged in screening of various indigenous herbal and metallic drugs for their potential use in peptic ulcer diseases, taking lead from Ayurveda and have reported an...

AIM To study the association of Helicobacter pylori infection with chronic antral gastritis in peptic ulcer disease patients and healthy population of Kashmir. METHODS 50 peptic ulcer patients (duodenal ulcer = 46, gastric ulcer = 2 and combined duodenal and gastric ulcer = 2) and 30 asymptomatic healthy volunteers were included in this study. Peptic ulcer was diagnosed on endoscopic examinat...