Peptic ulcer disease prevalence is decreasing in the West, except in certain populations such as immigrants. [2] A UK population-based cohort study reported an overall incidence of uncomplicated peptic ulcer as being 0.75 cases per 1,000 person-years, declining from 1.1 to 0.52 cases per 1,000 person-years between 1997 and 2005. A reduction in H. pylori-related peptic ulcers, changing patterns ...

Gastric biopsy specimens from 156 adult patients from southern Estonia suffering from chronic gastritis, peptic ulcer disease, and perforated peptic ulcer were analyzed by PCR. The cagA gene was evenly distributed throughout 87% of the specimens from the patients with the different gastric diseases. The presence of the cagA gene correlated with that of vacA signal sequence type s1a (99%). Howev...

This study was conducted to determine the prevalence of Helicobacter pylori (H. pylori) and its associated factors among patients with peptic ulcer disease in Taiping Hospital. Consecutive peptic ulcer disease patients who had undergone esophagogastro-duodenoscopy were included. The H. pylori status was assessed by the rapid urease test. We excluded those who had active bleeding, a perforated p...

The prevalence of peptic ulcer disease in the general population of Kashmir, India, was determined by endoscopy in a randomly selected sample population of 2763 adults aged 15 years and above who were interviewed using a questionnaire. Of 239 persons with ulcer symptoms, 193 (80.7%) had an oesophagogastroduodenoscopy. A randomly selected 177 individuals from among the remaining population witho...

AIM To study the association of Helicobacter pylori infection with chronic antral gastritis in peptic ulcer disease patients and healthy population of Kashmir. METHODS 50 peptic ulcer patients (duodenal ulcer = 46, gastric ulcer = 2 and combined duodenal and gastric ulcer = 2) and 30 asymptomatic healthy volunteers were included in this study. Peptic ulcer was diagnosed on endoscopic examinat...

Persistent exacerbation of a peptic ulcer may lead to a complicated peptic ulcer (perforation or/and bleeding). The management of complicated peptic ulcers has shifted from acid-reducing vagotomy, drainage, and gastrectomy to simple local suture or non-operative (endoscopic/angiographic) hemostasis. We were interested in the long-term effects of this trend change. In this study, complicated pep...

Gastrointestinal perforations are a complication of 2-10% of duodenal ulcers. There are a variety of etiologies associated with duodenal ulcer formation and its complications. Corticosteroid use is associated with an increased risk of duodenal ulcer perforation, with the first documented case in 1950. Other important medications associated with perforation include NSAIDS and opioids. Beyond med...

Objectives: To develop an easy applicable diagnostic scoring rule to determine the presence of peptic ulcers in dyspeptic patients in the primary care setting, and to evaluate whether Helicobacter pylori (H pylori) testing has added value to optimal history taking. Design: Cross-sectional study. Setting: Patients selected from general practitioner’s offices in the area of Utrecht, the Netherlan...

Peptic ulcer disease is usually diagnosed on the basis of well recognised symptoms confirmed by endoscopy or barium study. Within the community an unknown number of people, however, may have peptic ulcer disease without symptoms, some of whom present only because of haemorrhage or perforation. Roughly a third of the cases of perforated peptic ulcer, for example, occur in people without any prev...