OBJECTIVE The role of mast cells as the key effector of allergic inflammation, anaphylactic inflammatory reactions and in the pathogenesis of chronic inflammation, is well-known. The present study is adopted to compare mast cells and inflammatory cells within periapical granuloma and cysts and localize the mast cells and quantify their number in the periapical cysts so as to propose a role of m...

background: bone resorption is one of the main features of inflammatory periapical lesions and is mainly mediated by interleukin-1 beta (il-1β), tumor necrosis factoralpha (tnf-α) and prostaglandin-e2 (pge2). recent investigations of these lesions revealed that pharmacological modulation may be possible. objective: the aim of this study was to evaluate the effect of ibuprofen on il-1β, tnf-α an...

A referred patient presented with a lesion of endodontic origin located at the apex of tooth #27. The tooth had been endodontically treated and re-treated. A periapical radiograph revealed a close relationship between the lesion and the maxillary sinus. A cone-beam computed tomography scan confirmed that the lesion had invaded the sinus cavity. The treatment plan consisted of periapical surgery...

Chronic apical periodontitis (CAP) is one of the most common endodontic diagnosis caused by microbial infection within root canal system affected tooth. Endodontic therapy possible treatment modalities for CAP, but prognosis depends on numerous factors. The size periapical lesion always singled out as significant, its increase drastically decreases degree success therapy. Certain periapex radio...

Ameloblastoma is a benign tumor; whose importance lies in its potential to grow to enormous size with resulting bone deformity. Unicystic ameloblastoma (UA) is a less encountered variant of amelobastoma. The neoplastic nature of the lesion becomes evident only when the enucleated material is available for histologic examination. Although its predilection is for the posterior mandibular region, ...

It has been observed that the root canal treatment for the preservation of tooth having periapical pathology has shown over 90% of success whereas in the case where the canal is calcified, perforated, ledge is formed, and cases where symptoms still exist after treatment, endodontic treatment may not be the solution in attaining a successful treatment. Thus Apisectomy would generally be done to ...