BACKGROUND AND OBJECTIVES Vitamin D and folate are highly UV sensitive, and critical for maintaining health throughout the lifecycle. This study examines whether solar irradiance during the first trimester of pregnancy influences vitamin D receptor (VDR) and nuclear folate gene variant occurrence, and whether affected genes influence late-life biochemical/clinical phenotypes. METHODOLOGY 228 ...

Periconceptional intake of folic acid has demonstrated to be effective to reduce the frequency of neural tube defects, and food fortification has been one of the strategies implemented to increase it. An update is herein presented on the reduced prevalence of neural tube defect cases in the post-fortification period in Argentina and an estimation of cases averted in the 2005-2013 period as a re...

Objective: To evaluate the awareness of need for folic acid supplementation and also actual intake during periconceptional period to prevent neural tube defects.Methods: The study involved a questionnaire survey conducted among 100 women attended antenatal visit in Department Obstetrics Gynecology, Yenepoya Medical College, Mangalore, Karnataka. data were collected over March 2022 December 2022...

Adaptive growth responses of the embryo and fetus to nutritional restraint are important in ensuring early survival, but they are implicated in the programming of hypertension. It has been demonstrated that kidney growth and nephrogenesis are each regulated by intrarenal factors, including the insulin-like growth factors, glucocorticoids, and the renin-angiotensin system. Therefore, we have inv...

In 2008, planned folic acid fortification for the prevention of Neural Tube Defects (NTD) was postponed. Concurrently, the economic recession may have affected dietary folic acid intake, placing increased emphasis on supplement use. This study examined folic acid supplement use in 2009. A cross-sectional survey of 300 ante-natal women was undertaken to assess folic acid knowledge and use. Assoc...

INTRODUCTION Deficiency of folic acid (FA) has been identified as a risk factor for neural tube defects (NTDs) as well as other congenital anomalies. Thus, periconceptional folate supplementation is recommended for all women planning to get pregnant. METHODS We conducted a KAP (knowledge, attitude, practice) survey to investigate the use of FA and its appropriateness. The survey included a sa...

BACKGROUND To assess socioeconomic inequality in periconceptional folic acid supplementation in China. METHODS We used data of periconceptional folic acid (FA) supplementation of rural Chinese women from the National Free Preconception Health Examination Project from 2010 to 2012 and socioeconomic level data from the National Bureau of Statistics. We used logistic models to assess the associa...

OBJECTIVE: To examine the risk of birth defects in relation to lack of use of periconceptional vitamins or supplements containing folic acid and diabetes. STUDY DESIGN: The National Birth Defects Prevention Study (1997–2004), a multicenter, population-based case-control study of birth defects (14,721 case and 5,437 control infants). Cases were categorized into 18 types of heart defects and 26 n...

BACKGROUND Obesity in women of reproductive age has deleterious effects on reproductive and offspring health. In this study, we aimed to evaluate the association between the magnitude of periconceptional body-mass index (BMI) change and maternal and neonatal outcomes in obese infertile women who participated in the LIFEstyle study. The LIFEstyle study was a randomized controlled trial, evaluati...