BACKGROUND Whether acupuncture is effective for relieving perimenopausal syndrome has been controversial recently. In this article, we report the protocol of a randomized controlled trial using acupuncture to treat perimenopausal syndrome, aiming to answer this controversy. DESIGN A multicenter randomized controlled trial with two parallel arms is underway in China. Two hundred and six women ...

Dysfunctional uterine bleeding (DUB) is a clinical term used to describe bleeding not attributable to any underlying organic pathological condition. A total of 187 patients were included in the present study which were categorized in reproductive (<40 yrs), perimenopausal (40-50yrs) and postmenopausal (>50yrs) age groups. One hundred sixteen cases (62%) were in reproductive age group, 47 cases ...

In a perimenopausal model of middle-aged rats, the astrocyte estrogen receptor-alpha (ERa): ER-beta (ERb) ratio increased with the onset of acyclicity (constant estrus, CE) in association with impaired neurotrophic responses to estradiol (E2). We report additional data on irregular cycling (IR) from this study of 9 month old perimenopausal subgroups. In particular, irregular cyclers (IR) also s...

The changes in serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FHS), estradiol, and progesterone that occur both early and late in reproductive life were characterized and compared with findings in young, normal women and in patients with certain menstrual disorders. A total of 50 complete menstrual cycles in 37 were examined. Five distinct patterns of hormonal regulatio...

Introduction: Subclinical hypothyroidism (SCH) is common in elderly women. It is associated with serious complications. Substantial number of patients have risk of SCH getting converted into primaryhypothyroidism. Aim of the study: The objectives of present study is to find out the prevalence of SCH in perimenopausal women and its relation to cholesterol levels in patients attending the medicin...

Polycystic ovary syndrome (PCOS), a hyperandrogenic disorder, is the commonest endocrinopathy in premenopausal women. This syndrome is associated with fertility problems, clinical manifestations of hyperandrogenism and metabolic disturbances, particularly insulin resistance and obesity. There is a great body of evidence that patients with PCOS present multiple cardiovascular risk factors and cl...

Cardiovascular risk is poorly managed in women, especially during the menopausal transition when susceptibility to cardiovascular events increases. Clear gender differences exist in the epidemiology, symptoms, diagnosis, progression, prognosis and management of cardiovascular risk. Key risk factors that need to be controlled in the perimenopausal woman are hypertension, dyslipidemia, obesity an...

BACKGROUND Physical activity may be an effective way of preventing or attenuating menopause-related symptoms, and it has been shown to improve quality of life in menopausal women. However, there have been some inconsistencies regarding between exercise and menopausal symptoms, and study investigating this association has been scarce in Korea. In this study, the association between physical acti...

BACKGROUND Subsyndromal depression (SSD) is considered as a predictor for future depressive disorders, however whether white matter abnormalities are involved in the high-susceptibility of women to depressive disorders during perimenopause is unknown. The purpose of this study was to investigate fractional anisotropy (FA) in the white matter of the whole brain in perimenopausal women with SSD u...

Objective: This prospective study was undertaken to assess the sensitivity and specificity of color flow mapping and pulse Doppler waveform in identifying malignancy preoperatively in adnexal masses in perimenopausal women. Materials and methods: A total of 100 cases with adnexal masses in perimenopausal women were scanned, underwent color flow mapping and pulsed Doppler waveform studies. These...