BACKGROUND Treatment of intrabony defects is an important therapeutic goal of periodontal therapy. The goal of this consensus report was to critically appraise the evidence for the available approaches for promoting periodontal regeneration in intrabony defects. In addition to evaluating the effectiveness of new regenerative approaches for intrabony defects, recommendations for future research ...

Periodontal disease is a major public health issue and the development of effective therapies to treat the disease and regenerate periodontal tissue is an important goal of today's medicine. Regeneration of periodontal tissue is perhaps one of the most complex process to occur in the body. Langer and colleagues proposed tissue engineering as a possible technique for regenerating the lost period...

Tissue engineering is a highly promising field of reconstructive biology that draws on recent advances in medicine, surgery, molecular and cellular biology, polymer chemistry, and physiology. The objective of using tissue engineering as therapeutic application has been to harness its ability to exploit selected and primed cells together with an appropriate mix of regulatory factors, to allow gr...

Regenerative treatment of periodontal defects with an agent, or procedure, requires that each functional stage of reconstruction be grounded in a biologically directed process. With this paradigm, we contended the way of periodontal regeneration through the application of current knowledge in the fields of molecular and cell biology, developmental biology and tissue engineering principles as ap...

Periodontal surgery seeks for tissue regeneration. There is a new grafting material called platelet-rich fibrin (PRF), with multiple properties and one of them is regeneration. This study aimed to assess the regeneration efficacy of Platelet-rich fibrin in periodontal surgery. Were performed several computerized literature searches for randomized controlled trials (RCTs). That evaluated regener...

Barrier membranes are used in periodontal applications with the aim of supporting periodontal regeneration by physically blocking migration of epithelial cells. The present work proposes a combination of chitosan (CHT) with bioactive glass nanoparticles (BG-NPs) in order to produce a novel guided tissue and bone regeneration membrane, fabricated by solvent casting. The CHT/BG-NP nanocomposite m...

The potential use of stem cell based therapies for the repair and regeneration of various tissues offers a paradigm shift that may provide alternative therapeutic solutions for a number of diseases. The use of either embryonic stem cells (ESCs) or induced pluripotent stem cells in clinical situations is limited due to cell regulations and to technical and ethical considerations involved in gene...

background: bone loss is one of the hallmarks of periodontitis. hence, a major focus of research into periodontal regeneration has concentrated on the initiation of osteogenesis. osteoinduction requires the differentiation of mesenchymal cells into osteoblasts with subsequent formation of new bone. the present study has been carried out to evaluate periodontal bone regeneration in intrabony def...

Regeneration is defined as a reproduction or reconstruction of a lost or injured part in a way that both form and function of lost tissues are completely restored (Wikesjö and Selvig, 1999; Caton and Greenstein, 1993; Machtei, 1997; World Workshop in Periodontology, 1996). Regenerative periodontal therapy aims to predictably restore the tooth’s supporting apparatus which has been lost following...