This case report is about the novel use of the anti-CD20 antibody, rituximab, in the treatment of a 41 year old woman with stiff person syndrome. She was admitted to hospital as an emergency with prolonged and painful extensor spasms affecting the neck and back, arms, and legs. The disease had progressed despite a favourable initial response to conventional treatment with intravenous immunoglob...

Stiff-person syndrome (SPS) is a rare neurologic disorder characterized by waxing and waning muscular rigidity, stiffness and spasms. Three subtypes have been described: paraneoplastic, autoimmune and idiopathic. Rhabdomyolysis has been described in the paraneoplastic variant, but to our knowledge no case has been reported involving the autoimmune variant. We report a case report of a 50-year-o...

Stiff person syndrome (SPS) is a rare disorder characterized by continuous muscle activity causing severe rigidity and episodic spasms in axial and limb muscles (1). According to the diagnostic criteria, normal motor and sensory examination is the rule. Hyperactive deep tendon reflexes may be observed, but extensor plantar reflexes are rare (1,2,3,4). Here, by presenting this case with atypical...

Steven R. Zeiler, Joseph Dedrick Jordan, Benjamin M. Greenberg, Peter W. Kaplan The Johns Hopkins Hospital, Department of Neurology, Pathology 627C 600 N. Wolfe Street, Baltimore, MD 21287 University of North Carolina, 919.966.5547 UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9003 The Johns Hopkins Bayview Medical Center, Department of Neurology, 4940 Eastern Avenue,...

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Master Degree Student, Laboratory of Panic & Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, INCT Translational Medicine, Rio de Janeiro RJ, Brazil; Assistant Professor, Neurology Service, State of Rio de Janeiro University, Rio de Janeiro RJ, Brazil; Assistant Professor, Federal University of State of Rio de Janeiro, Rio de Janeiro RJ, Brazil; Associate Professor. L...

A 9-year-old female child presented with a history of falls, weight loss, diffuse leg pain, and progressive gait disorder, following 1 previous event described as a tonic–clonic seizure. She had increased thyroid volume, brisk symmetric reflexes, abnormal gait, and painful spasms of the paraspinal musculature. Thyroid function tests indicated biochemical hyperthyroidism, and thyrotropin recepto...