60 vs. 61 to 90 degrees) and randomized to CCh or placebo 2:1 in favour of the former. Post hoc meta-analysis of IMPRESS I and II data revealed that men treated with CCh showed a mean 34% improvement in penile curvature, representing a mean ±SD −17.0±14.8 degree change per subject, compared with a mean 18.2% improvement in placebo treated men, representing a mean −9.3±13.6 degree change per sub...

Peyronie and Dupuytren are pathologies characterized by the appearance of localized fibrotic lesions in an organ. These disorders originate from excessive production collagen tissue provoking dysfunction functional limitations to patients. Local administration collagenase is most used treatment for these fibrotic-type diseases, but a high lability enzyme limits its therapeutic efficacy. Herein,...

OBJECTIVES To report the principles of penile resculpturing of different deformities caused by M. Peyronie: restoration of penile length, girth and shape with or without penile prosthesis implantation. METHODS In the period between February 2007 and March 2009, we performed grafting surgery for M. Peyronie in 98 patients aged between 24 and 72 years (mean 52 years). Penile deformities were di...