Leukemia inhibitory factor (LIF) and Indian hedgehog (Ihh) are essential for embryo implantation in mice and are regulated by the actions of 17beta-estradiol (E2) and progesterone, respectively. The present study examined the effect of LIF on Ihh and Ihh-related factors in the uterine luminal epithelium during the implantation period using a DNA microarray. Expression of Ihh mRNA reached its pe...

This paper addresses the expression of the epidermal growth factor (EGF) gene by human breast tumor biopsy samples. Northern analysis was used to demonstrate the presence of an approximately S-kilobase inR.NA which specifically hybridized with radiolabeled human EGF complementary DNA in some human breast tumor biopsy samples. Quantitation of EGF niKN'A in 60 human breast tumor biopsies using th...

Abrupt climatic change, during the Late Quaternary in northern Europe, can be identified using different proxy data sources from sedimentary archives. The Last Glacial-Interglacial Transition (LGIT) (16-8 ka BP) is one such period that provides evidence of well-defined millennial scale climatic oscillations and associated reorganisation of ecosystems. Imprinted upon these longer term episodes a...

PURPOSE To investigate whether longitudinal functional PET imaging of mammary tumors using the radiopharmaceuticals [(18)F]FDG (to measure glucose uptake), [(18)F]FES [to measure estrogen receptor (ER) levels], or [(18)F]FFNP [to measure progesterone receptor (PgR) levels] is predictive of response to estrogen-deprivation therapy. EXPERIMENTAL DESIGN [(18)F]FDG, [(18)F]FES, and [(18)F]FFNP up...

Purpose: To investigate whether longitudinal functional PET imaging of mammary tumors using the radiopharmaceuticals [F]FDG (to measure glucose uptake), [F]FES [to measure estrogen receptor (ER) levels], or [F]FFNP [to measure progesterone receptor (PgR) levels] is predictive of response to estrogendeprivation therapy. Experimental Design: [F]FDG, [F]FES, and [F]FFNP uptake in endocrine-sensiti...

The progesterone receptor (PgR), a sex steroid hormone receptor that binds progesterone is critical for normal breast development. The PgR (+331G/A, rs10895068) promoter polymorphism is associated with cancer risk possibly by altering the expression of progesterone receptor B isoform. Previous studies have provided inconsistent results. To validate the association between the PgR +331G/A polymo...

Traumatic brain injury (TBI) is an important and costly medical problem for which no clinically proven treatment currently exists. Studies in rodents and humans have shown beneficial effects of progesterone (P4) on both mortality and functional outcomes following TBI. Neuroprotective effects of P4 in TBI likely involve the classical nuclear progesterone receptors (Pgr) that are widely distribut...

The conservation of plant genetic resources (PGR) is an important task that requires collaborative effort from many stakeholders. For this, common means of data exchange and effective methods to profit from the collected information need to be established. In this paper, we describe a demonstrator promoting findability of PGR, according to the FAIR (Findable, Accessible, Interoperable & Reusabl...

The estrogen receptor (ER) gene is located on chromosome 6. The aim of our study was to investigate whether numerical chromosomal aberrations were reflected in estrogen/progesterone receptor (PgR) status and staining pattern. Fine-needle aspirates from 51 breast carcinomas were investigated immunocytochemically for ER/PgR and by in situ hybridization technique using digoxigenin-labeled alpha-sa...

BACKGROUND Roots and leaves of the Cermela Hutan (Phyllanthus gomphocarpus Hook. F) plant were studied to determine antioxidant activity, phytochemical compounds, proportion of carbohydrate, crude protein, moisture, ash, fat, total phenolic content (TPC), and total flavonoid content (TFC). MATERIAL/METHODS Ten percent (10%) aqueous extract from both Phyllanthus gomphocarpus roots (PGR) and le...