A sensitive method is presented for the spectrophotometric determination of phenothiazine derivatives of biological importance. The drugs namely, chlorpromazine hydrochloride (CPH), promethazine hydrochloride (PH), trifluoperazine hydrochloride (TFPH), prochlorperazine maleate (PCPM) and fluphenazine hydrochloride (FPH) are reacted with a fixed amount of dichromate in acidic conditions. After t...

An analytical method has been described for the determination of mercury using a carbon paste electrode. Conditions for the preparation of the carbon paste electrode were optimized for low background current in order to use it for the determination of ultra trace levels of mercury. The carbon paste electrode was found to be a good electrode material for the determination of mercury. The optimiz...

Combined multichannel intraesophageal impedance-pH (MII-pH) monitoring is currently the the gold standard method to diagnosis of gastroesophageal reflux disease (GERD). A standard MII-pH catheter has six pairs of impedance electrodes. Multiple impedance-measuring within the esophagus allows determination of direction of bolus movement within the esophagus. So that MII is used as a good esophage...

Surface charge and isoelectric point of leather play an important role in the production of leather. However, a precise and rapid method for the determination of leather surface charge and isoelectric point is unavailable nowadays due to the complexity of the structure of leather, especially for chromefree tanned leather. Therefore, it is necessary to develop a quantitative determination method...

Simple, quantitative assays to measure pH in tissue could improve the study of complicated biological processes and diseases such as cancer. We evaluated multispectral fluorescence imaging (MSFI) to quantify extracellular pH (pHe) in dye-perfused, surgically-resected tumor specimens with commercially available instrumentation. Utilizing a water-soluble organic dye with pH-dependent fluorescence...

One hundred eighty-three patients had simultaneous blood and pleural fluid pH determinations. Thirty-six effusions were transudates, and 147 were exudates. In 46 effusions, the pleural fluid pH was less than 7.30; all 46 were exudates. A pleural fluid pH less than 7.30 was associated with the following six diagnoses: (1) empyema; (2) malignancy; (3) collagen vascular disease; (4) tuberculosis; ...

A flow-through spectrophotometric bulk optode for the flow-injection determination of thiocyanate is described. As active constituents, the optode incorporates the lipophilized pH indicator 5-octadecanoyloxy-2-(4-nitrophenylazo)phenol and methyltridodecyl ammonium chloride, dissolved in a plasticized poly(vinyl)chloride membrane entrapped in a cellulose support. The optode is applied, in conjun...

A sensitive kinetic method for spectrophotometric determination of acarbose is developed and validated for the determination of the drug in bulk and pharmaceutical formulations. The drug was estimated in simulated gastrointestinal media i.e., 0.1 M HCl (pH 1.2) and phosphate buffer (pH 6.8). The method involves the oxidation of acarbose by treating it with a strong oxidizing agent (potassium pe...

A sensitive, simple method for the determination of trace amounts of samarium by spectrophotometry is described based on the formation of the samarium-chrome azurol S (CAS) complex in micellar medium. The molar absorptivities of the complexes at pH 7.5 at 505 nm were 3.6x10(4) and 1.4x10(5) l mol(-1) cm(-1) for water media and cetylpyridinium chloride (CPC), respectively. Beer's law is obeyed f...

A plastic membrane electrode for the determination of methacycline hydrochloride was fabricated based on the use of methacycline-tetraphenylborate as the electroactive substance, and dioctylphtalate as the plasticizing agent. It was found that the potential responses of the electrode were influenced by pH of the tested solution when pH>3. Under the condition of pH 2.6, the linear response range...