Exposure to Escherichia coli during pregnancy may cause serious problems such as anemia, premature birth and an increased risk of inflammation the lining brain in fetus. Mahkota Dewa (Phaleria macrocarpa) is a medicinal plant that widely known used treat allergies chronic diseases. One compounds contained flavonoids. There certain mechanism action flavonoids inhibiting bacteria namely by damagi...

This research aimed to determine the potential protective effects ofPhaleria macrocarpafruit extracton rat gastric mucosal injury induced by ethanol andto clarify the roles of prostaglandinE2 (PGE2), transforming growth factor1 (TGF) and tumor necrosis factorTNF). Main methods: Seven groups of rats were orally pretreated with Tween20 as vehicle control group; Tween20 as ulcer group; 20 mg/kg of...

Fevicordin-A (FevA) isolated from Phaleria macrocarpa (Scheff) Boerl. seeds was evaluated for its potential anticancer activity by in vitro and in silico approaches. Cytotoxicity studies indicated that FevA was selective against cell lines of human breast adenocarcinoma (MCF-7) with an IC50 value of 6.4 µM. At 11.2 µM, FevA resulted in 76.8% cell death of T-47D human breast cancer cell lines. C...