Patient-specific image-based dosimetry is considered to be a useful tool to limit toxicity associated with peptide receptor radionuclide therapy (PRRT). To facilitate the establishment and reliability of absorbed-dose response relationships, it is essential to assess the accuracy of dosimetry in clinically realistic scenarios. To this end, we developed pharmacokinetic digital phantoms correspon...

An anthropomorphic head phantom, constructed from a water-equivalent plastic shell with only a spherical target, was modified to include a nonspherical target (pituitary) and an adjacent organ at risk (OAR) (optic chiasm), within 2 mm, simulating the anatomy encountered when treating acromegaly. The target and OAR spatial proximity provided a more realistic treatment planning and dose delivery ...

Introduction: The use of electronic portal imaging devices (EPIDs) is a method for the dosimetric verification of radiotherapy plans both pretreatment and in-vivo. The aim of this study was to test a 2D EPID-based dosimetry algorithm for dose verification of some plans inside a homogenous and anthropomorphic phantom and in-vivo, as well. Materials and Methods: </strong...

Purpose: To develop and validate a pre-treatment EPI dosimetry method on Varian TrueBeam linacs using continuous imaging, with reconstruction in a 3D cylindrical phantom geometry. Methods: Delivery of VMAT plans with continuous imaging is currently possible only in Research Mode on TrueBeam linacs, with images acquired in a proprietary format. An earlier technique was adapted to take advantage ...

background: craniospinal radiotherapy faces technical challenges which are due to the sensitivity of the location in which the gross tumor is, and to organs at risk around planning target volume. using modern treatment planning systems causes a reduction in the complexities of the treatment techniques. the most effective method to assess the dosimetric accuracy and the validity of the software ...

introduction the potential hazards posed by exposure to radiation from radon have been of great concern worldwide, since it is especially associated with increased risk of lung cancer. some radioisotopes of radon progeny deposited in the human lungs emit β particles followed by the γ rays. while γ rays are comparatively less damaging to the respiratory system than α and β particles, it is the p...

Dose distribution inside the human body due to external photon exposure was measured. Radiation detectors were imaging plate (IP) sheets and thermoluminescent dosimeters (TLD). Each IP sheet was installed between horizontally sliced pieces of a rando-phantom. TLDs were also installed inside/around the position of a target organ of the phantom. The rando-phantom was exposed to a photon beam of C...

For reasons of phantom material reproducibility, the absorbed dose protocols of the American Association of Physicists in Medicine (AAPM) (TG-51) and the International Atomic Energy Agency (IAEA) (TRS-398) have made the use of liquid water as a phantom material for reference dosimetry mandatory. In this work we provide a formal framework for the measurement of absorbed dose to water using ioniz...

Amorphous silicon (a-Si) electronic portal imaging devices (EPIDs) are x-ray detectors frequently used in radiotherapy imaging and dosimetry applications. EPIDs employ a copper plate and gadolinium oxysulfide phosphor screen with an array of a-Si photodiodes to indirectly detect incident radiation. In this study, a previously developed Monte Carlo (MC) model of an aSi EPID has been extended for...