Tissue simulating phantoms can provide a valuable platform for quantitative evaluation of the performance of diffuse optical devices. While solid phantoms have been developed for applications related to characterizing exogenous fluorescence and intrinsic chromophores such as hemoglobin and melanin, we report the development of a poly(dimethylsiloxane) (PDMS) tissue phantom that mimics the spect...

Tissue-equivalent phantoms that mimic the optical properties of human and animal tissues are commonly used in diffuse optical imaging research to characterize instrumentation or evaluate an image reconstruction method. Although many recipes have been produced for generating solid phantoms with specified absorption and transport scattering coefficients at visible and near-infrared wavelengths, t...

Photothermal OCT (PTOCT) provides high sensitivity to molecular targets in tissue, and occupies a spatial imaging regime that is attractive for small animal imaging. However, current implementations of PTOCT require extensive temporal sampling, resulting in slow frame rates and a large data burden that limit its in vivo utility. To address these limitations, we have implemented optical lock-in ...

Experiments performed on turbid phantoms demonstrate that spatially modulated illumination facilitates quantitative wide-field optical property mapping and tomographic imaging in turbid media.

The construction parameters and the composition of phantoms are strictly specified. Hence comparing the results from repeated imaging of a phantom with different imaging parameters allows isolation of the effect of the varied parameter. With this knowledge one can assign settings for optimum imaging of that particular phantom. Ideally the phantom would be exactly the same for every scan to allo...

Phantoms for radiation dosimetry, including physical phantoms for radiological use in medicine in particular, were introduced as early as the 1910s [1] while those for radiation protection dosimetry started to evolve in the late 1950s. This innovation was driven partly from the consensus that dose quantity for protection purposes should be assessed in “receptor conditions” instead of the tradit...

This symposium will review recent advances in the simulation methods for evaluation of novel breast imaging systems - the subject of AAPM Task Group TG234. Our focus will be on the various approaches to development and validation of software anthropomorphic phantoms and their use in the statistical assessment of novel imaging systems using such phantoms along with computational models for the x...

Abstract Elasticity of soft tissue is a valuable information to physicians in treatment and diagnosis diseases. The elastic properties can be estimated with ultrasound (US) shear wave imaging (SWEI). In US-SWEI, force push applied inside the resulting detected by high-frequency imaging. such as velocity mapped elasticity. Commonly, features are extracted tracking peak wave, estimating phase or ...

Backscatter and attenuation coefficient estimates are needed in many quantitative ultrasound strategies. In clinical applications, these parameters may not be easily obtained because of variations in scattering by tissues overlying a region of interest (ROI). The goal of this study is to assess the accuracy of backscatter and attenuation estimates for regions distal to nonuniform layers of tiss...

Optical imaging techniques are treated with utmost importance due to their noninvasive and relatively inexpensive qualities. They have obvious advantages for continuous monitoring of physiological changes over diagnostic modalities like radiography and computed tomography which utilizes ionic radiation. Tomography is mathematical technique to get cross sectional details of an object from multip...