Tractable classes of binary CSP and binary Max-CSP have recently been discovered by studying classes of instances defined by excluding subproblems. In this paper we characterise the complexity of all classes of binary Max-CSP instances defined by forbidding a single subproblem. In the resulting dichotomy, the only non-trivial tractable class defined by a forbidden subproblem corresponds to the ...

Credibility is an old yet modern topic. It has a particular significance in the current trend of market economy. However, China is facing a serious crisis of credibility nowadays. This paper proposes the suggestion of building credibility system in China from legal perspective.

List of abbreviations 4 Introduction 5 The history and development of the new guideline ICH Topic Q8 5 The contents and requirements according to the new guideline 9 Comparison of the current guideline ICH Q8 with the previous guideline 15 Comparison of both guidelines – a summary 28 The term Design Space-Integration into ICH Q8, Q9 and Q10 29 Requirements of the new guideline for the innovatin...