Pharmacokinetic studies are an integrated part of the development program of a new drug. They are intended to define the time course of drug and major metabolite concentrations in plasma and other biological fluids in order to obtain information on absorption, distribution, metabolism, and elimination. In preclinical studies, pharmacokinetics (PK) is often used to interpret toxicological result...

A general equation was derived, which directly describes the mathematical relationship between the allometrically predicted pharmacokinetic (PK) parameters in humans and the body weights of animal species (along with their corresponding measured PK parameters). It was shown, with use of the derived equation, that the predicted values in humans, based on combinations of animal species commonly u...