The roles of the extracellular domain of type II TGF-β receptor (TBRII-ECD) in physiological processes ranging from development to cancer to wound healing render it an attractive target for exploration with chemical tools. For such applications, large amounts of active soluble protein are needed, but the yields of TBRII-ECD we obtained with current folding protocols were variable. To expedite t...

 Background & Objective:  Migraine is an occasional headache that represents neurological and gastrointestinal symptoms, as well as changes in the autonomic nervous system. Biofeedback is a non-pharmacological technique used to treat migraine headaches and is proven to reduce headaches and improve performance. The present study aimed to compare the efficacy of biofeedback and pharmacological tr...

Dynamic clamp, a hybrid-computational-experimental technique that has been used to elucidate ionic mechanisms underlying cardiac electrophysiology, is emerging as a promising tool in the discovery of potential anti-arrhythmic targets and in pharmacological safety testing. Through the injection of computationally simulated conductances into isolated cardiomyocytes in a real-time continuous loop,...

background & aim: pain is the main stressful factor in patients hospitalized in intensive care units(icu). non-pharmacological methods for pain relief are preferred by icu patients due to lack of considerable side effects. the present research aims to determine the effect of tens on pain intensity followed by surgery in patients hospitalized in intensive care units. setting of the study was bes...

background and objective: genus salacia l. (celastraceae) is a woody climbing medicinal plant consisting of about 200 species with many endangered species located throughout the world’s tropical areas. various parts of the plant as food, functional food additive and tea have been extensively used to treat a variety of ailments like diabetes and obesity as well as inflammatory and skin diseases....