Four novel azo disperse dyes based on 1-4-bromobenzyl-4-phenylpiperazine were synthesized in two steps, using alkylation and azo coupling reactions. Chemical structure of the dyes was characterized and confirmed by the Ultraviolet Visible UV-Visible, Fourrier Transform Infrared FT-IR, Proton Nuclear Magnetic Resonance 1H NMR and Carbon Nuclear Magnetic Resonance 13C NMR analyses. The solvatochr...

Thiophene substituted chalcones (1a-e) were cyclised with thiourea in presence of potassium hydroxide to get 4-substituted-6-(thiophen-2-yl)pyrimidine-2-thiols (2a-e) which were then stirred with methyl iodide to obtain 4-substituted-2-(methylsulfanyl)-6-(thiophen-2-yl)pyrimidines (3a-e). Compounds (3a-e) were refluxed with different N-methylpiperazine and N-phenylpiperazine to afford 4-substit...

A series of new analogues of 3-[3-(4-arylpiperazinyl)-propyl]-cyclohexane-1’,5-spirohydantoin (2), with aromatic ring fused in amide moiety (4–9) were synthesized and evaluated for affinity at 5-HT and 5-HT receptors. The influence of the substitution mode in the phenyl ring of phenylpiperazine moiety on the affinity for both receptors has been discussed. The most potent 5-HT (9, K = 53 nM) and...

Calcium/calmodulin-dependent protein kinase-II (CamK-II) is a major neuronal protein which plays a significant role in the cellular process of long-term potentiation (LTP), and vesicular release of neurotransmitters. Here, we show that KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4- phenylpiperazine, a specific cell-permeable inhibitor of CamK-II substantially protected neurons...