Twenty five blood samples from 6-month to 5-year old children with visceral leishmaniasis were analysed for various enzymes. Aspartate transaminase (AST), alanine transaminase (ALT), lactate dehydrogenase (LD) and its various isoenzymes were estimated in the serum, while glucose 6-phosphate dehydrogenase (G6PD) was measured in red blood cells. For comparison, blood samples from healthy chi...

glucose-6-phosphate dehydrogenase (g6pd) deficiency is a common enzyme deficiency in the world. it's prevalence iniranis about 12% in male & about 1% in female. the present study did examine the relation between the development of preeclampsia and g6pd deficiency. it was investigated whether or not the risk of preeclampsia in g6pd deficient women is higher than that in normal pregnant women. a ...

Glucose 6-phosphate dehydrogenase deficiency in an elite long-distance runner Glucose 6-phosphate dehydrogenase (G6PD) deficiency is the world's most common enzymopathy 1 and caused by mutations in the X-chromosomal G6PD gene. The enzyme catalyzes the first reaction of the hexose monophosphate shunt, which results in 2 main products: pentose phosphate sugars and the reduced form of nicotinamide...

RATIONALE Vascular smooth muscle cell (VSMC) survival under stressful conditions is integral to promoting vascular repair, but facilitates plaque stability during the development of atherosclerosis. The cytoskeleton-associated smooth muscle (SM) 22α protein is involved in the regulation of VSMC phenotypes, whereas the pentose phosphate pathway plays an essential role in cell proliferation throu...

The isoenzymes of glucose 6-phosphate dehydrogenase (G6PD) and láclate dehydrogenase (LDH) were studied in R3230AC mammary adenocarcinomas and normal mammary glands of Fischer rats at various times during and after the administration of estradiol-17/3. Total activities of G6PD and LDH were elevated in response to treatment with estrogen; however, only certain isoenzyme species were increased b...

The activity of red blood cell Glucose 6-phosphate dehydrogenase (G6PD) in one hundred and twenty six healthy male individuals who are Nigerians residing in Jos was evaluated. The enzyme activity was determined quantitatively by spectrophotometer assay method. The activity of red cell G6PD enzyme was subnormal in 20 % of the population studied. This agrees with previous report of the prevalence...

Two patients with acute monocytic leukemia and heterozygous for the Mediterranean variant of the X-linked enzyme, glucose-6-phosphate dehydrogenase (G6PD), were investigated to determine the number and type of progenitor cells involved. Mosaicism for Mediterranean G6PD was assessed by the different rate of utilization of 2-deoxy glucose-6-phosphate (2dG6P) by normal and Mediterranean variants o...

Human glucose-6-phosphate dehydrogenase (G6PD) is a crucial enzyme in the pentose phosphate pathway, and serves an important role in biosynthesis and the redox balance. G6PD deficiency is a major cause of neonatal jaundice and acute hemolyticanemia, and recently, G6PD has been associated with diseases including inflammation and cancer. The aim of the present study was to conduct a search of the...

glucose-6-phosphate dehydrogenase (g6pd) in humans is an x-chromosome-linked disorder and housekeeping enzyme, vital for the survival of every cell. it catalyses the oxidation of glucose-6-phosphate to 6-phospho gluconate in the first committed step of the pentose phosphate pathway, which provides cells with pentoses and reducing power in the form of nadph. nadph is required to protect the cell...

PURPOSE We recently demonstrated that histone deacetylase (HDAC) inhibitors can "reprogram" differentiated triple-negative breast cancer cells to become quiescent stem-like cancer cells. We hypothesized that the metabolic state of such cells differs from that of their differentiated progeny. RESULTS In untreated cells, glucose uptake was higher in ALDH+ cells than in ALDH- cells (p = 0.01) bu...