The clinical use of alkylating drugs represents an important contribution toward the chemotherapeutic management of certain forms of human cancer. Several recent reports summarize the palliative responses obtained with triethylenemelamine (TEM), triethylene phosphoramide (TEPA), and Myleran (Busulfan) in patients with malignant neoplasias of lymphatic or myelogenous origin (2, 3, 11, 12). The c...

A Convenient Synthesis of Novel Phosphoramide Mustard Analogues of 2-Arylquinolone Jinwei Yuan a , Xiaolan Chen a , Lingbo Qu a b , Shouren Zhang a , Jiansha Lu a & Yufen Zhao a c a Key Laboratory of Organic Chemistry and Chemical Biology, Henan Province, Department of Chemistry , Zhengzhou University , Zhengzhou, P. R. China b Henan University of Technology, Henan Province , Zhengzhou, P. R. C...

A proton NMR method for the drtermination of salvation numbers of alkaline earth cations with hexamethyl phosphoramide (HMPA) in nitromethane (NM) as diluents is described. The method is based on monitoring the resonance frequency of HMPA protons as a function of HMPA / metal ion molar ratio at constant metalion concentration. The average salvation number of cations,  , at any HMPA / metal ...

Over the last several years there has been a huge increase in the development and applications of new efficient organocatalysts for enantioselective pericyclic reactions, which represent one of the most powerful types of organic transformations. Among these processes are cycloaddition reactions (e.g., [3+2]; formal [3+3]; [4+2]; vinylogous [4+2] and 1,3-dipolar cycloadditions), which belong to ...

Silyl ketene imines derived from a variety of alpha-branched nitriles have been developed as highly useful reagents for the construction of quaternary stereogenic centers via the aldol addition reaction. In the presence of SiCl4 and the catalytic action of chiral phosphoramide (R,R)-5, silyl ketene imines undergo extremely rapid and high yielding addition to a wide variety of aromatic aldehydes...

a proton nmr method for the drtermination of salvation numbers of alkaline earth cations with hexamethyl phosphoramide (hmpa) in nitromethane (nm) as diluents is described. the method is based on monitoring the resonance frequency of hmpa protons as a function of hmpa / metal ion molar ratio at constant metalion concentration. the average salvation number of cations,  , at any hmpa / metal ion ...

Mercury(II) exhibits a strong preference for linear coordination which has been attributed to relativistic effects splitting the 6p orbitals and promoting sp hybridization. If the two ligands attached to the mercury(II) ion are weak donors, the metal ion can act as a good Lewis acid and expand its coordination number. Moreover, mercury has a special affinity for softer bases, such as S and N at...