UVA is a major bio-active component in solar irradiation, and is shown to have immunomodulatory and anti-inflammatory effects. The detailed molecular mechanism of UVA action in regard to calcium signaling in mast cells, however, is not fully understood. In this study, it was found that UVA induced ROS formation and cytosolic calcium oscillations in individual rat mast cells. Exogenously added H...

In article number 2101262, Gang Chen, Hélder A. Santos, Wenguo Cui, and co-workers construct a light-controlled nanosystem with in situ modulated particle size by near-infrared irradiation synergistic effect using photochemotherapy for tumor suppression. The at the leads to rapid shedding of polye thylene glycol enhanced cellular uptake. versatile design this flexibility opens new avenues cance...

The risks incurred from increased exposure to UVA II (320-340 nm) (i.e. during sunscreen use and extended outdoor exposure, tanning parlors) are not well understood. Therefore, we explored the effects of UVA II on skin immune responses in humans. After a single local exposure (4 minimum erythemal dose [MED]) using a xenon are lamp filtered with a narrow bandpass filter (335 +/- 5 nm full width ...

background: ultraviolet (uv) radiation is divided into three regions: uva, uvb, and uvc. both the quality and quantity of solar uv radiation vary with various factors including the elevation of the sun above the horizon, as well as absorption and scattering of uv photons by molecules in the atmosphere, notably ozone and clouds. it is clear that whereas a moderate amount of uv exposure is benefi...

BACKGROUND Diesel exhaust [diesel exhaust particles (DEPs) and their extracts (DPE)] and ultraviolet A radiation (UVA) are two ubiquitous environmental factors that have been identified as essential risk factors for various benign or malignant human diseases, either alone or in combination with other agents. OBJECTIVES We aimed to investigate the synergistic effects of DPE and UVA at low-dose...

BACKGROUND PUVA photochemotherapy is indicated to treat mycosis fungoides, either as monotherapy in the earlier stages of the disease or in combination with other drugs in more advanced stages of evolution. OBJECTIVES – To evaluate PUVA photochemotherapy response in patients with mycosis fungoides. METHODS From January 1996 to November 2003, 17 patients with a diagnosis of mycosis fungoides wer...

A prototype UVA dosimeter that is responsive to the UVA wavelengths only has been developed for measurement of personal exposures. The chemical phenothiazine, cast in thin film form and which is responsive to both the UVA (320400 nm) and UVB (280-320 nm) part of the spectrum was used and filtered with mylar. This combined system responded to the UVA wavelengths only and underwent a change in op...

UVA (315–400 nm), which constitutes f95% of the UV irradiation in natural sunlight, represents a major environmental challenge to the skin and is clearly associated with human skin cancer. Here, we show that a low, nonlethal dose of UVA induces dose-dependent cell cycle progression in human HaCaT keratinocytes. We found that UVA induced cyclin D1 accumulation, whereas siRNA knockdown of cyclin ...

Propolis is a resinous material collected by honeybees from several plant sources. This research aimed at showing its protective effect against UVA-induced apoptosis of human keratinocyte HaCaT cells. Using Hoechst staining, it was demonstrated that propolis (5 and 10 μg/mL) significantly inhibited the apoptosis of HaCaT cells induced by UVA-irradiation. Propolis also showed the protective effe...