present for a photodynamic effect to occur; photosensitizer, light and oxygen. The photosensitizer is administered in a stable form (ground state). It is then promoted to a higher energy state (singlet state) by light of a specific wavelength. The excited photosensitizer is then unstable and can release energy in one of three ways, i.e. emission of heat, emission of light, or conversion to an i...

Photodynamic therapy (PDT) is a locally administered therapy currently being investigated in various clinical and preclinical settings. Tumor-host interaction is an important determinant of tumor biology and response to treatments. Here we report for the first time the effects of PDT on an orthotopic, murine mammary tumor model. PDT utilizes two individually nontoxic components: (a) the localiz...

Photodynamic therapy (PDT) is a treatment approach that uses a photosensitizer, and light, to kill cancer cells. The treatment consists of two stages. In the first stage, the photosensitizer is accumulated in cell, following topical or systemic administration. In the second stage, the sensitized tumor is exposed to light at a specific wavelength that is appropriate for the absorption spectrum o...

The scientific work analyzes the effectiveness of Photoditazine photosensitizer for sanation poultry products, namely broiler chicken carcasses and eggs to reduce bacterial contamination final product. quality products processed with was assessed from point view veterinary sanitary expertise microbiology. Specific quantitative identification microflora carried out during treatment photosensitiz...

BACKGROUND AND OBJECTIVES In the last decade, many different kinds of therapies have emerged as a consequence of advances in the field of applied technology. It is known that low level laser therapy contributes to tissue healing; however, the use of photodynamic therapy (PDT) in healing and the scar formation processes has not been fully explored. The present study analyses the effect of low le...

Photodynamic therapy (PDT) utilizes optical energy to activate a pre-administered photosensitizer drug to achieve a localized tumor control. In the presented study, PDT mediated with a second-generation photosensitizer, WST09 (TOOKAD, Steba Biotech, The Netherlands), is investigated as an alternative therapy in the treatment of prostate cancer. In vivo canine prostate is used as the animal mode...

Photodynamic therapy (PDT) is a modality for the removal of solid tumors, in which a photosensitized tumor is irradiated with intense light to activate the photosensitizer and induce local hyperoxidative stress. The production of reactive molecular species at the tumor site results in massive tumor cell death, vascular shutdown, and a prolonged antitumor immune response. Promising results have ...

Photodynamic therapy (PDT) is a selective and minimally invasive therapeutic approach, involving the combination of a light-sensitive compound, called a photosensitizer (PS), visible light and molecular oxygen. The interaction of these per se harmless agents results in the production of reactive species. This triggers a series of cellular events that culminate in the selective destruction of ca...

The efficacy of photodynamic therapy (PDT) depends upon the delivery of both photosensitizing drug and oxygen. In this study, we hypothesized that local vascular microenvironment is a determinant of tumor response to PDT. Tumor vascularization and its basement membrane (collagen) were studied as a function of supplementation with basement membrane matrix (Matrigel) at the time of tumor cell ino...

A ROLE FOR REACTIVE OXYGEN SPECIES IN PHOTODYNAMIC THERAPYbyMICHAEL PRICEDecember 2012Advisor:David Kessel, Ph.D.Major:Cancer BiologyDegree:Doctor of PhilosophyPhotodynamic therapy (PDT) is based on the ability of certain photosensitizingagents to selectively localize in neoplastic cells and their vasculature. Subsequentirradiation at a wavele...