Efferent activity in the phrenic nerve was recorded during induced hypotension and hypertension in anaesthetized, paralysed, artificially ventilated dogs. Changes in arterial pressure were induced with infusions of sodium nitroprusside, noradrenaline and angiotensin II, after which ventilation was adjusted to return the PaCO2 near to control values. The PaO2 was maintained above chemoreceptor t...

The basis for the relationship between the discharges in the external cartized cats that were vagotomized, paralyzed, and artificially ventilated. Ive discharge (with the period of the cycle of phrenic nerve activity) is extrinsically imposed on central sympathetic networks by elements of the brainstem respiratory oscillator. However, a number of observations made in the present study contradic...

The objects of this paper are (a) to report on a study of mediastinal shift and apico-basal diameters of the lungs in a series of 80 patients undergoing phrenic nerve crush and pneumoperitoneum therapy for pulmonary tuberculosis: (b) to discuss the mechanism and therapeutic significance of the mediastinal shift. Although studies of mediastinal shift following phrenic nerve paralysis alone have ...

Abbreviations: AP 5 adductor pollicis; BAMPS 5 bilateral anterior magnetic phrenic nerve stimulation; CINMA 5 critical illness neuromuscular abnormality; CDAP 5 compound diaphragm action potential; CMS 5 cervical magnetic stimulation; ES 5 bilateral electrical phrenic nerve stimulation; ETT 5 endotracheal tube; GBS 5 Guillain-Barré syndrome; LFF 5 low-frequency fatigue; Pimax 5 maximal inspirat...

UNLABELLED Hiccups are actions consisting of sudden contractions of the diaphragm and intercostals followed by a sudden inspiration and transient closure of the vocal cords. They are generally short lived and benign; however, in extreme and rare cases, such as esophageal carcinoma, they can become persistent or intractable, up to and involving significant pain, dramatically impacting the patien...

A 69-year-old man with a history of severe nonischemic cardiomyopathy managed with a cardiac resynchronization-defibrillator presented to the outpatient clinic with uncomfortable pulsation over the left upper-abdominal area when lying on his left side. He was hemodynamically stable. When he was recumbent in a left-lateral position, there were visible and palpable contractions of the left upper-...

T HE THOROUGH and oft-quoted experiments of Porter (I) were designed to determine the presence or absence of crossing connections between the descending inspiratory reticulospinal fibers of one side and the phrenic motor nuclei of the opposite side. In demonstrating the existence of such connections, Porter repeated an observation which had been made previously (z-4) and formulated an hypothesi...

Activation of serotonin 1A (5-HT(1A)) receptors has been shown to have diverse effects on respiration. The purpose of this study was to determine changes in respiratory motor pattern of phrenic nerve activity and respiratory rhythm after systemic application of specific 5-HT(1A) receptor agonist 8-hydroxy-2-di-npropylamino-tetralin (8-OH-DPAT). We hypothesized that systemic application of speci...