gundelia tournefortii l. is a well known plant in mountains of iran and is found all over the country. it traditionally has some medicinal applications. in this research, gundelia tournefortii l. seed was studied as a source of edible oil. oil was extracted with immersion method using diethyl ether as a solvent. acidity, saponification, ester, iodine, peroxide and refractive indices, average mo...

densely functionalized 3-(4-chlorophenyl)-5-(3-hydroxy-4-etoxyphenyl)-4,5-dihydro-1h-pyrazole-1-carboxamide was  synthesized in an expedient manner through specification and transamidation  respectively, of ester-functionalized pyrazoles. this synthetic protocol allowed for three diversifying steps in which appendages on the pyrazole scaffold were adjusted to optimize inhibition of protein kina...

It has been more than two decades since neuraxial opioids first underwent rigorous clinical study for use in humans. The intraspinal route of administration is now commonly used to administer anesthetics and analgesics. Addition of opioids to intraspinal administered local anesthetic provides an effective and prolonged analgesia. However, the physiochemical properties of opioids may influence t...

In this issue of Blood, Ciciliano et al demonstrate that thrombus formation in ferric chloride (FeCl3) thrombosis models relies on physiochemical, rather than biological, mechanisms.

A bacterial plasmid is a species of nonessential extrachromosomal deoxyribonucleic acid (DNA) that replicates autonomously as a stable component of the cell's genome. Naturally occurring plasmids range in size from one to several hundred kilobases and in copy number from one to several hundred per cell. Copy number is a fixed characteristic of any plasmid under constant conditions and is contro...