Partial oxidation of 2-, 3and 4-picolines has received much attention because their oxidation products, picolinic acid, nicotinic acid and isonicotinic acid, respectively, are valuable intermediates of vitamins, food additives and pharmaceuticals1)~16). For example, 2-pyridinecarbaldehyde and picolinic acid are vitamins, feed stocks for synthesis of physiologically active substances, dyes and o...

OBJECTIVE This study tested the hypothesis that supplementation of chromium picolinate (CrPic), 200 microg Cr/d, compared with an equivalent amount of picolinic acid (1720 microg) in CrPic and placebo, decreases body weight, alters body composition, and reduces iron status of women fed diets of constant energy and nutrients. METHODS We fed 83 women nutritionally balanced diets, used anthropom...

It has been suggested that picolinic acid (PIC), an endogenous metabolite of l-tryptophan, possesses neuro-protective and anti-proliferative effects within the CNS. However, the literature surrounding PIC is limited, and its exact endogenous function is not known. Picolinic acid is produced via the kynurenine pathway which has been implicated in the pathogenesis of a range of neuro-inflammatory...

Comparable to many amino acids, the title compound, C(6)H(5)NO(3), is a substitution product of picolinic acid. The mol-ecule shows approximate non-crystallographic C(s) symmetry. Like many amino acids, the mol-ecule is present in its zwitterionic state. Intra- as well as inter-molecular hydrogen bonds are observed, the latter connecting the mol-ecules into zigzag chains along the crystallograp...

A number of manganese-based catalysts employing ligands whose structures incorporate pyridyl groups have been reported previously to achieve both high turnover numbers and selectivity in the oxidation of alkenes and alcohols, using H(2)O(2) as terminal oxidant. Here we report our recent finding that these ligands decompose in situ to pyridine-2-carboxylic acid and its derivatives, in the presen...

The geometrical structures and photophysical properties of Ir(4,6-dFppy)₂(pic) (FIrpic) and its derivative (o-FIr, m-FIr, p-FIr) with dimethylamine substituted at the picolinic acid (N∧O) ligand were fully investigated by density functional theory and time-dependent density functional theory. The simulated electronic structure, as well as absorption and emission spectra of FIrpic are in good ag...

Recent studies have suggested a role for aminoacid catabolites as important regulators of macrophage (Mphi) activities. We reported previously that picolinic acid (PA), a tryptophan catabolite produced under inflammatory conditions and a costimulus with IFNgamma of Mphi effector functions, is a selective inducer of the Mphi inflammatory protein-1alpha (MIP-1alpha) and -1beta (MIPs), two CC-chem...