In a bioassay-guided search for acetylcholinesterase (AChE) inhibitors from 180 medicinal plants, an ethyl acetate extract of whole plants of Agrimonia pilosa ledeb yielded tiliroside (1), 3-methoxy quercetin (2), quercitrin (3) and quercetin (4). We report herein for the first time that all four flavonol compounds showed significant inhibitory effects on AChE, particularly quercetin (4), which...

The plant species Pimpinella serbica (Vis.) Drude, endemic to West Balkans, belongs the genus L. (Apiaceae) according newer botanical classification. Initially, was described as Pancicia Vis. and long considered a monotypic genus. Previous phytochemical investigations of this were limited essential oil analysis by GC?MS method. This is first study that includes LC-DAD?MS screening extracts root...

We have constructed restriction-site maps of the mtDNAs in 13 species and one subspecies of the Drosophila obscura group. The traditional division of this group into two subgroups (affinis and obscura) does not correspond to the phylogeny of the group, which shows two well-defined clusters (the Nearctic affinis and pseudoobscura subgroups) plus a very heterogeneous set of anciently diverged spe...

Melilotus suaveolens Ledeb is a traditional medicinal plant for treating inflammation-related disease. This explores the inner anti-inflammatory mechanism of n-butanol extract from M. suaveolens Ledeb. Inflammatory cellular model was established by lipopolysaccharide intervention on RAW264.7 cell line. Levels of secreted cytokines TNF-α, IL-1β, IL-6, NO and IL-10 in supernatant, mRNA expression...

Invertebrates were collected and identified from the stomach contents of eight mosquitofish (Gambusia affinis) populations in the northern Waikato region of New Zealand at 3-month intervals from December 1994 to September 1995. To investigate temporal and spatial patterns in dietary composition a novel analysis programme was created that used Gower's similarity coefficient. The analysis found d...

The article describes the features of plant community territory where Artemisia schrenkiana Ledeb, which grows in Urzhar District Abai Kazakhstan region, is found. research work was carried out by Universal geobotanical methods. As a result study, authors, with comprehensive analysis microclimatic state, terrain structure and flora composition Ledeb grows, described 163 species belonging to 116...

8-p-Hdroxybenzoyl tovarol (TAW) is a germacrane-type sesquiterpenoid that can be isolated from the roots of Ferula dissecta (Ledeb.) Ledeb. In this study, the growth inhibitory effects induced by TAW were screened on some types of tumor cells, and the mechanism was investigated on TAW-induced growth inhibition, including paraptosis and autophagy in human cervical cancer HeLa cells. TAW-induced ...

Cherry plum (Prunus divaricata Ledeb.) is a diploid fruit tree that belongs to the Rosaceae family. Anticarcinogenic activity of Prunus Ledeb. methanol extract was examined in lung cancer cell lines A549 and H1299 as well healthy line Beas-2b this study. The changes expression levels most frequently mutated oncogenes cancer, KRAS, EGFR, BRAF, PIK3CA were investigated well. In vitro cytotoxicity...