Regnase-1 is an RNase that directly cleaves mRNAs of inflammatory genes such as IL-6 and IL-12p40, and negatively regulates cellular inflammatory responses. Here, we report the structures of four domains of Regnase-1 from Mus musculus-the N-terminal domain (NTD), PilT N-terminus like (PIN) domain, zinc finger (ZF) domain and C-terminal domain (CTD). The PIN domain harbors the RNase catalytic ce...

In the present paper, tribological properties of untreated and magnetically treated EN8 medium-carbon steel were studied. Tribological tests performed using a pin-on-disc friction wear tester. The alternating magnetic field treatment has led to reduction in coefficient by 18% rate 41% decreases surface roughness scar width 30% 12% respectively. Examination means transmission electron microscopy...

OBJECTIVE To assess the magnitude and causes of over-diagnosis of prostatic intraepithelial neoplasia (PIN), as large differences are reported in the incidence of high-grade PIN, probably because of the variance in diagnosis and interpretation. PATIENTS AND METHODS Two urological pathologists prospectively reviewed 251 consecutive patients, received in consultation and who were diagnosed and ...

Plant development displays an exceptional plasticity and adaptability that involves the dynamic, asymmetric distribution of the phytohormone auxin. Polar auxin flow, which requires polarly localized transport facilitators of the PIN family, largely contributes to the establishment and maintenance of the auxin gradients. Functionally overlapping action of PIN proteins mediates multiple developme...

Pin structures on vector bundles are the natural generalization of Spin structures to the case of nonoriented bundles. Spin(n) is the central Z/2Z extension (or double cover) of SO(n) and Pin−(n) and Pin(n) are two different central extensions of O(n), although they are topologically the same. The obstruction to putting a Spin structure on a bundle ξ (= R → E → B) is w2(ξ) H(B;Z/2Z); for Pin it...

40 is a near branch, an analogous argument again shows that Pin(b) is q's lower-right quadrant. Thus, q is the closest connection between p, Pin(a) and Pin(b). Except for redundancies and pruning of sub-optimal trees, BB-SORT-C searches over all possible ways to construct a Steiner tree sequentially, such that each sink is added by a closest connection to some edge in the current tree. Thus, we...