Introduction: Rathke cleft cysts (RCC’s) are cystic sellar and supra sellar benign lesions which are thought to originate from the remnants of Rathke’s pouch. There are no specific clinical or radiological signs to differentiate them from other pituitary lesions. Presentation of Case: We report a 25-year-old female presented with hyperandrogenism and menstrual disorder, with the preliminary ...

Pituitary tumors, the most common intracranial tumors, lead to serious morbidity through the inappropriate secretion of pituitary hormones. The anomalous expression of microRNAs (miRNAs), which have a crucial status in the development and function of pituitary gland, promotes the tumorigenesis of hypothalamic-pituitary axis-related pituitary tumors. This mainly leads to alterations in the funct...

INTRODUCTION We aimed to investigate survivin and its splice variants DEx3 and 2B expressions in pituitary adenomas and normal pituitary glands using immunohistochemistry. MATERIAL AND METHODS The study group consisted of eight pituitary adenomas: five of non-functional tumors, two of GH-secreting tumors, and one PRL-secreting tumor. Eight healthy pituitary tissue samples obtained after autop...

background and importance: the coexistence of pituitary adenoma and another type of brain tumor is a very rare clinical scenario. even though such a presentation can be an incidental event but the possible pathogenesis of coexistence of different lesions in the sella and suprasellar region has not yet been elucidated. case presentation: two cases of concomitant sellar and suprasellar region tum...

We verified the advantages of using magnetic resonance imaging (MRI) for improving the diagnostic quality of growth hormone deficiency (GHD) in children with short stature caused by pituitary lesions. Clinical data obtained from 577 GHD patients with short stature caused by pituitary lesions were retrospectively analyzed. There were 354 cases (61.3%) with anterior pituitary dysplasia; 45 cases ...

Recently, Basic and Clinical Neuroscience published an article by Lim et al. (2016)  entitled Co-occurence of Pituitary Adenoma with Suprasellar and Olfactory Groove Meningiomas. They claimed it as the first case of co-occurence of these two malignancies. However, to our knowledge, this is not the first case reported in this regard. We reported the same case scenario in a 61-year-old woman...

In female, energy metabolism influences reproductive function by modulating the Hypothalamic Pituitary Ovarian axis including hypothalamic GnRH neuronal network, pituitary gonadotropin secretion and ovarian follicle growth steroidogenesis. Several hormones neuropeptides or metabolites are important signals between balance reproduction. These sensors mediate their action on cells through specifi...

Pituitary abscesses are infrequent entities, often forgotten and hence rarely included in the differential diagnosis of sellar lesions. However, given that they share clinical manifestations other more common pathologies this region, treatment pituitary is usually performed correctly without demonstrating a relevant delay therapeutic decisions when surgical options considered as alternative cho...